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Prescription only medicine

Venclyxto 100 mg Tablets

Venetoclax 100 mg

Venclyxto 100 mg Tablets is a trusted medication containing Venetoclax, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Venetoclax
Strength
100 mg
Form
Tablet
Manufacturer
AbbVie
Made in
Turkey
Prescription
Required
Commonly used forCancer
$2,072.00 per pack of 28 tablets

Prescription required — upload it at checkout.

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Chitra Shetty
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Venclyxto 100 mg Tablets?

Venetoclax is a targeted tablet for chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma, and — with azacitidine, decitabine or low-dose cytarabine — for acute myeloid leukaemia (AML) in people who cannot have intensive chemotherapy. It works in a different way from most cancer medicines: it removes a protein that stops leukaemia cells from dying.

Because it can kill large numbers of leukaemia cells quickly, treatment starts with a five-week 'ramp-up' — 20 mg, then 50, 100, 200 and finally 400 mg daily, each for a week — with blood tests and plenty of fluids so that the breakdown products of dying cells do not overload the kidneys (tumour lysis syndrome). The first doses of each step may be given in hospital depending on your risk.

Venetoclax is taken once a day with food. In CLL it is usually combined with obinutuzumab or rituximab for a fixed period, or with ibrutinib; in AML it continues as long as it works. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Venetoclax work?

Every cell has a built-in self-destruct programme (apoptosis) that removes it when it is damaged or no longer needed. Leukaemia cells stay alive by making too much of a protein called BCL-2, which holds that programme switched off. Venetoclax fits into BCL-2's binding pocket and displaces the proteins BCL-2 was holding back, so the self-destruct programme runs and the leukaemia cell dies. Because this happens quickly and to many cells at once, the ramp-up schedule and hydration exist to protect the kidneys from the debris.

BCL-2 blockade

Venetoclax binds the BH3-binding groove of BCL-2 with high affinity and selectivity.

Release of BIM/BAX

Pro-apoptotic proteins that BCL-2 had sequestered are freed and activate the mitochondrial death pathway.

Apoptosis

The leukaemia cell dies by programmed cell death — rapidly and in large numbers, hence the tumour lysis precautions.

Uses

What is Venetoclax used for?

Chronic lymphocytic leukaemia (CLL) / small lymphocytic lymphoma

Untreated (with obinutuzumab, fixed duration) or previously treated (with rituximab or alone), including 17p-deletion disease.

FDA EMA CDSCO
Acute myeloid leukaemia (AML), newly diagnosed

With azacitidine, decitabine or low-dose cytarabine, in adults 75 or older or unfit for intensive induction chemotherapy.

FDA EMA CDSCO

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Venclyxto 100 mg Tablets

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If less than 8 hours have passed, take it; if more, skip it and take the next dose at the usual time. If you vomit, do not replace the dose. During ramp-up, tell your team about any missed dose — you may need to repeat a step.

With food? Take with food and water — food increases absorption and the approved dose assumes it. Swallow whole. Avoid grapefruit, Seville oranges and starfruit.

Important safety information

Safety & warnings

Please read this section before taking Venclyxto 100 mg Tablets and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Low white blood cells (neutropenia)
  • Diarrhoea
  • Nausea
  • Anaemia, low platelets
  • Upper respiratory infection
  • Tiredness (fatigue)
  • Raised potassium, phosphate or uric acid (lab changes of tumour lysis)
  • Constipation, vomiting

Contact your doctor immediately if you notice:

  • Nausea, vomiting, muscle cramps, palpitations, confusion or passing very little urine — especially in the first days of each ramp-up step Seek emergency care — possible tumour lysis syndrome. This is why blood tests are done 6–8 and 24 hours after the first dose of each step.
  • Fever of 38°C or higher, chills, or signs of infection Go to the emergency department — neutropenic infection is a medical emergency.
  • Unusual bruising or bleeding Contact your team the same day — possible low platelets.
  • Severe diarrhoea or vomiting with dehydration Contact your team; dehydration increases tumour lysis risk.

Important: tell your doctor about these medicines

Taking Venetoclax with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong CYP3A inhibitors (ketoconazole, itraconazole, posaconazole, clarithromycin, ritonavir) Critical

    Increase venetoclax levels several-fold.

  • Moderate CYP3A inhibitors (fluconazole, diltiazem, verapamil, erythromycin, ciprofloxacin) and grapefruit Major

    Increase venetoclax levels.

  • P-glycoprotein inhibitors (amiodarone, cyclosporine, quinidine) Major

    Increase venetoclax levels.

  • Strong CYP3A inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce venetoclax levels and may make it ineffective.

  • Live vaccines Major

    Risk of infection; response reduced.

Pregnancy & breastfeeding

Venetoclax may harm an unborn baby. It should be avoided in pregnancy, and women who could become pregnant should use effective contraception during treatment and for at least 30 days after the last dose. Hormonal contraceptives may be less reliable — use an additional method.

Do not breastfeed during treatment or for one week after the last dose.

Venetoclax may reduce fertility in men, based on animal studies. Discuss sperm banking before starting if this matters to you.

For full prescribing information see: FDA prescribing information: Venclexta (venetoclax) — DailyMed

Storage

How to store Venclyxto 100 mg Tablets

Temperature

Store below 30°C (86°F).

Light & moisture

Keep in the original blister or bottle, protected from moisture.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Anticancer medicine: swallow whole, do not crush; wash hands after handling. Return unused tablets to a pharmacy.

Travelling

Carry in original packaging with your prescription and a haematologist's letter. Do not travel during the ramp-up weeks unless your team agrees — the blood-test schedule is tight.

Reviewed for accuracy

Medically reviewed content

Chitra Shetty

Chitra Shetty

B.Pharm, M.Pharm

Chitra Shetty is a licensed clinical pharmacist with 14 years of experience. She holds a B.Pharm and M.Pharm from Sambalpur University. At OnlineMeds, she reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

FAQ

Frequently asked questions

Why does the dose start so low and increase each week?

Venetoclax can kill leukaemia cells very quickly. If too many die at once their contents flood the blood — tumour lysis syndrome — which can harm the kidneys and heart. Starting at 20 mg and stepping up weekly, with blood tests and extra fluids, lets the body clear the debris safely. Never skip a step or start at the full dose.

[1] FDA prescribing information: Venclexta (venetoclax) — DailyMed

What is tumour lysis syndrome and how will I know?

A rush of potassium, phosphate and uric acid from dying cells. Warning signs are nausea, vomiting, muscle cramps, palpitations, confusion and passing little urine, usually within a day of a new dose level. Blood tests at 6–8 and 24 hours after each step catch it early; drink about 1.5–2 litres of water a day from two days before each step unless told otherwise, and take the uric-acid-lowering tablet you are given.

[4] Macmillan Cancer Support: Venetoclax (Venclyxto)

Why must I take Venclyxto 100 mg Tablets with food?

Food increases absorption several-fold and the approved dose was studied with a meal. Taking it fasting would deliver less drug than intended.

[1] FDA prescribing information: Venclexta (venetoclax) — DailyMed

Why did my haematologist cut my dose when I started an antifungal?

Azole antifungals and several antibiotics block the enzyme that clears venetoclax, raising its level several-fold. The dose is reduced — by half or by three-quarters depending on the medicine — while you take them, then restored. Always tell your team before starting any new medicine.

[1] FDA prescribing information: Venclexta (venetoclax) — DailyMed

Is treatment for a fixed time or ongoing?

It depends on the regimen. In CLL with obinutuzumab it is 12 months; with rituximab, 24 months — then it stops. In AML it continues for as long as it is working. Your haematologist will tell you the plan.

[3] EMA: Venclyxto — European public assessment report

Is Venclyxto 100 mg Tablets chemotherapy?

No. It is a targeted therapy that switches the leukaemia cell's own self-destruct programme back on. It does lower white cell counts, so infection precautions still apply.

[2] NCI Drug Information: Venetoclax

Do I need a prescription to order Venclyxto 100 mg Tablets?

Yes. Venetoclax is prescription-only. Upload your haematologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Venclexta (venetoclax) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=venclexta U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Venetoclax. https://www.cancer.gov/about-cancer/treatment/drugs/venetoclax National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. EMA: Venclyxto — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/venclyxto European Medicines Agency. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Venetoclax (Venclyxto). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/venetoclax Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #208573, NCI Drug Information, and NHS patient information.
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