Nexataf

Tablet

by Nexataf

Nexataf 25 mg Tablet

Tenofovir Alafenamide (TAF)

Nexataf 25 mg Tablet is a trusted medication containing Active Pharmaceutical Ingredient, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts

Active ingredient: Tenofovir Alafenamide (TAF)
Form: Tablet
Indication: HIV-1 infection, chronic Hepatitis B
Manufacturer: Nexataf

This medicine is available to order. Contact us for current pricing and availability.

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Overview

What is Tenofovir Alafenamide (TAF)?

Tenofovir alafenamide (TAF) is a newer prodrug of tenofovir designed to deliver the active drug more efficiently inside cells. Compared to the older TDF (tenofovir disoproxil fumarate), TAF uses a much lower dose (10–25 mg vs 300 mg), resulting in far lower plasma tenofovir levels and significantly less kidney and bone side effects.

Mechanism

How Does It Work?

Efficient cell uptake

TAF is a phosphonamidate prodrug that preferentially enters lymphocytes and hepatocytes, where it is converted to tenofovir diphosphate (TFV-DP).

Intracellular activation

Because activation occurs inside the target cell rather than in plasma, much lower doses achieve equivalent or higher intracellular TFV-DP concentrations than TDF, sparing kidneys and bones from high plasma exposure.

Chain termination

TFV-DP competes with dATP for incorporation into viral DNA, causing premature chain termination of HIV reverse transcription or HBV polymerase activity.

Dosage

How to Use

Timing

Once daily, at the same time each day

How to Take

Swallow whole with water. Can be taken with or without food.

Frequency

Once daily

With Food

Can be taken with or without food

Alcohol

Avoid excessive alcohol

Missed Dose

Take as soon as remembered. If close to next dose, skip the missed dose. Never double dose.

Safety

Side Effects & Precautions

Common Side Effects

Nausea
Headache
Fatigue
Abdominal pain
Diarrhoea

Serious Side Effects — seek help immediately

Lactic acidosis
Severe hepatomegaly with steatosis
Severe acute HBV exacerbation on discontinuation (HBV-infected patients)
Renal impairment (less common than TDF)

Who Should Not Take This

Concurrent use with TDF-containing products
Severe hepatic impairment

Value

Generic vs Brand

Generic (OnlineMeds)

Vemlidy

Price per unit

—

$800–$1400/month

Active ingredient

Identical

WHO-GMP certified

✓

Bioequivalent

✓

Reference

Storage

Storage & Handling

Temperature

Below 30°C in original bottle

Light

Keep in original bottle

Humidity

Do not remove desiccant; protect from moisture

Children

Keep out of reach of children.

Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from WHO-GMP certified manufacturers.

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Every batch tested for purity and bioequivalence.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

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Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

What is the difference between TAF and TDF in Nexataf 25 mg Tablet?

TAF (tenofovir alafenamide) is a newer prodrug that activates inside the target cell rather than in the bloodstream. This means a much lower dose (25 mg vs 300 mg for TDF) delivers equivalent or greater activity at the site of infection, while causing significantly less exposure to the kidneys and bones.

Is Tenofovir Alafenamide (TAF) safer for kidneys than older tenofovir?

Yes — clinical studies show TAF causes significantly less reduction in kidney function and less loss of bone density compared to TDF, because plasma tenofovir levels are much lower. It is preferred for patients with pre-existing kidney disease or osteoporosis.

Can Nexataf 25 mg Tablet treat Hepatitis B as well as HIV?

Yes. TAF (as Vemlidy) is specifically approved for chronic Hepatitis B at 25 mg once daily. It is also present in HIV combination tablets (e.g. Biktarvy, Descovy) where it treats both HIV and any co-existing HBV infection.

What happens if I stop taking Nexataf 25 mg Tablet when I have Hepatitis B?

Stopping TAF abruptly in HBV-infected patients can cause a severe flare of Hepatitis B that may result in serious liver damage or liver failure. Always consult your doctor before stopping, and liver function will need to be monitored closely for several months after discontinuation.

⚠ BLACK BOX WARNING

Severe acute exacerbation of Hepatitis B has been reported in HBV-infected patients who discontinued TAF. Hepatic function should be monitored closely for at least several months in these patients.

Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with nucleoside analogues.

Drug Interactions

Drug / Substance	Effect	Action
Rifampicin	Reduces TAF levels — may compromise efficacy	Avoid; consult specialist for alternative
Rifabutin	Moderately reduces TAF exposure	Increase TAF dose or avoid
P-gp inducers (carbamazepine, St John's Wort)	Reduce TAF plasma levels	Avoid concurrent use
TDF-containing products	Duplication of tenofovir — increased toxicity	Do not use concurrently

Approved Indications

HIV-1 infection (in combination regimens) FDA / EMA
Chronic Hepatitis B in adults and children ≥ 2 years (Vemlidy) FDA / EMA

References

Gilead Sciences. FDA Prescribing Information: Vemlidy (tenofovir alafenamide). ↗
WHO. WHO Consolidated Guidelines on HIV Treatment, 2021. ↗

Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.

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