Biomus
Capsule
Biomus 1 mg Capsules
Tacrolimus
Biomus 1 mg Capsules is a trusted medication containing Active Pharmaceutical Ingredient, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.
Quick Facts
- Active ingredient: Tacrolimus
- Form: Capsule
- Indication: Organ Transplant Rejection Prophylaxis
- Manufacturer: Biomus
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Overview
What is Tacrolimus?
Tacrolimus is a calcineurin inhibitor immunosuppressant used to prevent organ rejection after kidney, liver, and heart transplants. It works by suppressing T-lymphocyte activation and proliferation. It requires careful therapeutic drug monitoring (blood level testing) because the therapeutic window is narrow — too little risks rejection, too much risks toxicity.
Mechanism
How Does It Work?
1
FKBP12 binding
Tacrolimus binds to the cytosolic protein FKBP12 (FK-binding protein), forming a complex.
2
Calcineurin inhibition
The tacrolimus-FKBP12 complex inhibits calcineurin, blocking the dephosphorylation of NFAT (nuclear factor of activated T cells).
3
T-cell suppression
Without NFAT dephosphorylation, cytokine gene transcription (especially IL-2) is blocked, preventing T-lymphocyte activation and proliferation that would otherwise trigger graft rejection.
Dosage
How to Use
Timing
Twice daily (immediate release) at consistent 12-hour intervals; once daily (extended release) at the same time each day
How to Take
Take on an empty stomach or at least 1 hour before or 2–3 hours after a meal for consistent absorption. Do not mix formulations.
Frequency
Twice daily (IR) or once daily (ER)
With Food
Avoid high-fat meals — significantly alter absorption. Avoid grapefruit juice — inhibits CYP3A4, raising tacrolimus levels.
Alcohol
Avoid alcohol — increases CNS effects and interacts with immunosuppression
Missed Dose
Take as soon as remembered if within the same dosing period. If close to next scheduled dose, contact your transplant team — do not guess with this medication.
Safety
Side Effects & Precautions
Common Side Effects
- Tremor
- Headache
- Elevated blood glucose / new-onset diabetes
- Elevated blood pressure
- Kidney impairment (nephrotoxicity)
- Diarrhoea
Serious Side Effects — seek help immediately
- Nephrotoxicity — requires regular kidney function monitoring
- Neurotoxicity — seizures, encephalopathy (high blood levels)
- Increased risk of serious infections and opportunistic infections
- Post-transplant lymphoproliferative disorder (PTLD) — rare lymphoma
- QT prolongation
Who Should Not Take This
- Known hypersensitivity to tacrolimus or polyoxyl 60 hydrogenated castor oil (IV formulation)
- Co-administration with ciclosporin (increases nephrotoxicity risk)
Value
Generic vs Brand
Generic (OnlineMeds)
Prograf / Tacrograf
Price per unit
$30.00
$300–$800/month
Active ingredient
Identical
Identical
WHO-GMP certified
✓
✓
Bioequivalent
✓
Reference
Storage
Storage & Handling
Temperature
Below 25°C
Light
Keep in original packaging, away from light
Humidity
Store in a dry place
Children
Keep out of reach of children.
Why OnlineMeds
Why Buy From Us
Manufacturer Direct
Sourced directly from WHO-GMP certified manufacturers.
Quality Verified
Every batch tested for purity and bioequivalence.
Global Delivery
Discreet shipping to UK, US, AU, EU and beyond.
Licensed Pharmacy
Regulated and compliant with international pharmacy standards.
FAQ
Frequently Asked Questions
Why do I need regular blood tests while taking Biomus 1 mg Capsules?
Tacrolimus has a narrow therapeutic window — the difference between too little (rejection risk) and too much (toxicity) is small. Blood level monitoring ensures your dose keeps you in the safe range. Your transplant team will schedule these tests regularly.
Can I eat grapefruit while taking Tacrolimus?
No. Grapefruit and grapefruit juice inhibit the CYP3A4 enzyme that breaks down tacrolimus, causing unpredictable increases in blood levels. Avoid grapefruit products throughout your treatment.
Does Biomus 1 mg Capsules increase my risk of infection?
Yes. Tacrolimus suppresses the immune system to prevent transplant rejection. This increases susceptibility to bacterial, viral, and fungal infections. Avoid close contact with sick individuals and inform your doctor promptly if you develop fever or signs of infection.
What should I do if I accidentally miss a dose of Biomus 1 mg Capsules?
Contact your transplant coordinator or doctor promptly — do not simply double the next dose. Tacrolimus dosing requires precise management, especially in the early post-transplant period.
⚠ BLACK BOX WARNING
Increased susceptibility to infection and the possible development of lymphoma and other malignancies may result from immunosuppression with tacrolimus. Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should use tacrolimus.
Drug Interactions
| Drug / Substance | Effect | Action |
|---|---|---|
| Strong CYP3A4 inhibitors (fluconazole, clarithromycin) | Markedly increase tacrolimus blood levels — nephrotoxicity and neurotoxicity risk | Reduce tacrolimus dose; monitor blood levels closely |
| Strong CYP3A4 inducers (rifampicin, carbamazepine) | Markedly reduce tacrolimus blood levels — rejection risk | Increase tacrolimus dose; monitor blood levels closely |
| Ciclosporin | Additive nephrotoxicity | Contraindicated combination |
| Grapefruit juice | CYP3A4 inhibition increases tacrolimus exposure unpredictably | Avoid grapefruit throughout treatment |
References
- Astellas Pharma. Prograf (tacrolimus) prescribing information. ↗
Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.
Biomus 1 mg Capsules
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