Avonza

Tablet

by Avonza

Avonza Tablet

Efavirenz

Avonza Tablet is a trusted medication containing Active Pharmaceutical Ingredient, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts

Active ingredient: Efavirenz
Form: Tablet
Indication: HIV-1 infection
Manufacturer: Avonza

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Overview

What is Efavirenz?

Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with other antiretrovirals to treat HIV-1. It is typically taken once daily at bedtime due to neuropsychiatric side effects that diminish during sleep.

Mechanism

How Does It Work?

NNRTI binding

Efavirenz binds directly to HIV reverse transcriptase at a site adjacent to the active site, causing a conformational change.

Enzyme inhibition

The conformational change inhibits RNA-dependent and DNA-dependent DNA polymerase activity, blocking viral DNA synthesis.

Viral suppression

Without reverse transcriptase, HIV cannot convert its RNA genome to DNA, halting replication inside CD4+ T cells.

Dosage

How to Use

Timing

Once daily, preferably at bedtime

How to Take

Swallow capsule or tablet whole. Take on an empty stomach — a high-fat meal increases exposure and side effects.

Frequency

Once daily

With Food

Take on an empty stomach or with a light meal. Avoid high-fat meals.

Alcohol

Avoid alcohol — worsens CNS side effects

Missed Dose

Take as soon as remembered. If within 4 hours of next dose, skip. Never double dose.

Safety

Side Effects & Precautions

Common Side Effects

Dizziness
Vivid dreams / nightmares
Difficulty concentrating
Rash (usually mild)
Nausea

Serious Side Effects — seek help immediately

Severe rash (Stevens-Johnson syndrome — rare)
Serious psychiatric symptoms (depression, suicidal ideation)
Liver toxicity (monitor LFTs)
Immune Reconstitution Inflammatory Syndrome (IRIS)

Who Should Not Take This

Concurrent use of voriconazole (standard doses)
Severe hepatic impairment
First trimester of pregnancy (avoid if possible — teratogenic risk)

Value

Generic vs Brand

Generic (OnlineMeds)

Sustiva / Stocrin

Price per unit

$55.00

$500–$800/month

Active ingredient

Identical

WHO-GMP certified

✓

Bioequivalent

✓

Reference

Storage

Storage & Handling

Temperature

Below 25°C

Light

Keep in original packaging

Humidity

Dry place

Children

Keep out of reach of children.

Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from WHO-GMP certified manufacturers.

Quality Verified

Every batch tested for purity and bioequivalence.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

Licensed Pharmacy

Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

Why do I need to take Avonza Tablet at bedtime?

Efavirenz causes dizziness and vivid dreams in many patients, especially during the first few weeks. Taking it at bedtime means you sleep through most side effects. They typically lessen after 2–4 weeks.

Can Efavirenz cause mood changes?

Yes. Efavirenz is known to cause neuropsychiatric effects including depression, anxiety, and rarely suicidal thoughts. Report any persistent mood changes to your doctor immediately.

Is Avonza Tablet safe to take during pregnancy?

Efavirenz should be avoided in the first trimester if possible due to evidence of neural tube defects in animal studies. Discuss alternatives with your HIV specialist if you are pregnant or planning a pregnancy.

How long before Efavirenz controls my viral load?

Most patients achieve significant viral suppression within 12–24 weeks. Consistent daily dosing without missed doses is essential for long-term virological success.

Drug Interactions

Drug / Substance	Effect	Action
Voriconazole	EFV dramatically reduces voriconazole levels; EFV levels increase	Contraindicated at standard doses
Rifampicin	Reduces EFV plasma levels by ~26%	Increase EFV dose to 800mg if ≥50kg
Hormonal contraceptives	EFV may reduce contraceptive efficacy	Use barrier contraception in addition

Approved Indications

HIV-1 infection in adults and children ≥3 months FDA / EMA

References

Bristol-Myers Squibb. Sustiva (efavirenz) prescribing information. ↗

Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.

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