Daclaxen

Tablet

by Daclaxen

Daclaxen 60 mg Tablets

Daclatasvir

Daclaxen 60 mg Tablets is a trusted medication containing Active Pharmaceutical Ingredient, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts

Active ingredient: Daclatasvir
Form: Tablet
Indication: Chronic Hepatitis C (genotypes 1, 3, 4)
Manufacturer: Daclaxen

This medicine is available to order. Contact us for current pricing and availability.

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Overview

What is Daclatasvir?

Daclatasvir (DCV) is a direct-acting antiviral targeting the NS5A protein of the Hepatitis C virus. It is most commonly used in combination with sofosbuvir for HCV genotypes 1, 3, and 4. The sofosbuvir/daclatasvir combination achieves SVR12 rates of 90–98% across genotypes in 12–24 weeks. It is an affordable, widely available generic in developing markets.

Mechanism

How Does It Work?

NS5A binding

Daclatasvir binds to domain I of the HCV NS5A protein, disrupting its role in viral RNA replication and assembly.

Replication complex disruption

NS5A is essential for organising the membranous web where HCV replication occurs. Daclatasvir prevents the formation of functional replication complexes.

Viral assembly inhibition

In addition to blocking replication, NS5A inhibitors including daclatasvir impair the assembly and secretion of new HCV particles.

Dosage

How to Use

Timing

Once daily, at the same time each day

How to Take

Take with or without food.

Frequency

Once daily

With Food

No significant food interaction

Alcohol

Avoid alcohol throughout HCV treatment

Missed Dose

Take as soon as remembered. If close to next scheduled dose, skip the missed dose. Never double dose.

Safety

Side Effects & Precautions

Common Side Effects

Headache
Fatigue
Nausea
Diarrhoea

Serious Side Effects — seek help immediately

Serious symptomatic bradycardia when co-administered with amiodarone (class effect with sofosbuvir combination)
Hepatitis B reactivation in HBV/HCV co-infected patients
Elevated liver enzymes

Who Should Not Take This

Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John's Wort)
Known hypersensitivity to daclatasvir

Value

Generic vs Brand

Generic (OnlineMeds)

Daklinza / Natdac

Price per unit

—

$150–$350/month (generic)

Active ingredient

Identical

WHO-GMP certified

✓

Bioequivalent

✓

Reference

Storage

Storage & Handling

Temperature

Below 30°C

Light

Store in original packaging

Humidity

Dry place

Children

Keep out of reach of children.

Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from WHO-GMP certified manufacturers.

Quality Verified

Every batch tested for purity and bioequivalence.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

Licensed Pharmacy

Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

Can Daclatasvir cure Hepatitis C on its own?

No. Daclatasvir must always be combined with sofosbuvir (and sometimes ribavirin) to treat HCV. Combination therapy achieves SVR12 rates above 90% in 12–24 weeks.

How long do I need to take Daclaxen 60 mg Tablets?

Treatment duration with daclatasvir plus sofosbuvir is typically 12 weeks for most patients, or 24 weeks for patients with cirrhosis or HCV genotype 3. Your doctor will determine the appropriate course.

Can I take Daclaxen 60 mg Tablets with HIV medicines?

Daclatasvir interacts with several HIV protease inhibitors and NNRTIs (particularly efavirenz). Dose adjustments may be needed — your HIV/HCV specialist will review all your medications before starting treatment.

What does SVR12 mean and how do I know if Daclatasvir has worked?

SVR12 (sustained virological response at 12 weeks) means the HCV virus is undetectable in your blood 12 weeks after finishing treatment. This is the standard measure of treatment success for Hepatitis C. Your doctor will order a blood test at that point to confirm.

⚠ BLACK BOX WARNING

Test all patients for current or prior HBV infection before initiating daclatasvir. HBV reactivation has been reported during or after HCV treatment and may result in fulminant hepatitis or death.

Drug Interactions

Drug / Substance	Effect	Action
Strong CYP3A4 inducers (rifampicin)	Dramatically reduces daclatasvir exposure	Contraindicated
Strong CYP3A4 inhibitors (clarithromycin)	Increases daclatasvir exposure — adjust dose to 30mg	Reduce daclatasvir dose to 30mg once daily
Atazanavir (HIV protease inhibitor)	Increases daclatasvir exposure significantly	Reduce daclatasvir dose to 30mg once daily

Approved Indications

Chronic HCV genotype 1 (with sofosbuvir) FDA / EMA
Chronic HCV genotype 3 (with sofosbuvir) EMA (WHO-recommended)
Chronic HCV genotype 4 (with sofosbuvir) EMA

References

Bristol-Myers Squibb. Daklinza (daclatasvir) prescribing information. ↗
WHO. Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection. ↗

Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.

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