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Prescription only medicine

Enzamide 40 mg Capsules

Enzalutamide 40 mg · Generic equivalent of Xtandi

Enzamide 40 mg Capsules is a trusted medication containing Enzalutamide, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Enzalutamide
Strength
40 mg
Form
Capsule
Manufacturer
Intas Pharmaceuticals Ltd.
Made in
India
Prescription
Required
Commonly used forProstate Cancer
$125.00 per pack of 28 capsules

Prescription required — upload it at checkout.

Generic equivalent of Xtandi — up to 80% less than the branded price

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by G. Selvaraman
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Enzamide 40 mg Capsules?

Enzalutamide is a hormone-therapy medicine for prostate cancer, taken by mouth once a day. It is used when the cancer keeps growing despite testosterone-lowering treatment (castration-resistant disease, with or without spread), for newly diagnosed metastatic disease alongside testosterone-lowering treatment, and for high-risk disease that has returned after surgery or radiotherapy.

Prostate cancer cells grow when testosterone activates their androgen receptor. Enzalutamide is a second-generation anti-androgen: it blocks the receptor far more strongly than older drugs such as bicalutamide, and it also stops the receptor entering the cell nucleus and switching on growth genes. Testosterone-lowering injections are usually continued with it.

Enzalutamide comes as 40 mg capsules or tablets (four a day) and, from some manufacturers, as an oral solution. It is taken with or without food. Tiredness, hot flushes and raised blood pressure are the common side effects; a small risk of seizures means it is used with care in people with a seizure history. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Enzalutamide work?

Testosterone drives prostate cancer by binding to the androgen receptor, which then travels into the cell nucleus and switches on growth genes. As the cancer becomes resistant to hormone treatment it makes many more receptors and becomes sensitive to even tiny amounts of hormone. Enzalutamide blocks the receptor at three points: it stops testosterone binding, it stops the receptor moving into the nucleus, and it stops the receptor attaching to DNA. That triple block is why it works in cancers that have stopped responding to older anti-androgens. It does not lower testosterone itself, so the injections continue.

Receptor blockade

Enzalutamide binds the androgen receptor with roughly five- to eight-fold higher affinity than bicalutamide, and has no agonist activity.

Nuclear exclusion

The bound receptor cannot translocate into the nucleus.

DNA binding blocked

Any receptor that does reach the nucleus cannot bind DNA or recruit co-activators, so androgen-driven transcription stops.

Uses

What is Enzalutamide used for?

Metastatic castration-resistant prostate cancer

Before or after docetaxel chemotherapy.

FDA EMA CDSCO
Non-metastatic castration-resistant prostate cancer

Rising PSA on androgen-deprivation therapy without visible spread.

FDA EMA
Metastatic castration-sensitive prostate cancer

With androgen-deprivation therapy.

FDA EMA CDSCO
Non-metastatic castration-sensitive prostate cancer with high-risk biochemical recurrence

Alone or with an LHRH agonist.

FDA EMA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Enzamide 40 mg Capsules

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? Take it as soon as you remember the same day; if it is the next day, skip it and continue as usual. Never double up.

With food? With or without food. Swallow capsules or tablets whole; do not open, crush or chew. Oral solution: measure with the supplied syringe.

Important safety information

Safety & warnings

Please read this section before taking Enzamide 40 mg Capsules and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Tiredness, weakness (asthenia)
  • Hot flushes
  • Raised blood pressure
  • Falls and bone fractures
  • Headache, dizziness
  • Memory or concentration difficulty
  • Anxiety, sleep disturbance
  • Breast tenderness or enlargement
  • Dry skin, itching
  • Constipation, diarrhoea, reduced appetite

Contact your doctor immediately if you notice:

  • A seizure (fit) or loss of consciousness Stop and seek emergency care — seizures occur in under 1% but the risk is higher with a seizure history, brain injury or certain medicines.
  • Severe headache, confusion, vision loss, seizure — with very high blood pressure Seek emergency care — a rare brain condition (PRES) has been reported.
  • Chest pain, breathlessness, sudden weakness Call emergency services — heart attack and stroke are more frequent on androgen-deprivation therapy plus enzalutamide.
  • A fall or a bone that breaks easily Seek assessment; bone-strengthening treatment and fall precautions may be advised.
  • Difficulty swallowing, choking, food going the wrong way Tell your team — swallowing difficulty with aspiration has been reported.
  • Severe blistering rash Stop and seek urgent care.

Important: tell your doctor about these medicines

Taking Enzalutamide with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong CYP2C8 inhibitors (gemfibrozil) Major

    Increase enzalutamide exposure substantially.

  • Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce enzalutamide levels.

  • CYP3A4, CYP2C9 and CYP2C19 substrates (warfarin, midazolam, omeprazole, some statins, hormonal contraceptives, many others) Critical

    Enzalutamide is a STRONG inducer and can make these medicines ineffective or unpredictable.

  • Medicines that lower the seizure threshold (tramadol, bupropion, some antipsychotics and antidepressants) Major

    Additive seizure risk.

Pregnancy & breastfeeding

Enzalutamide is not indicated for women and can harm an unborn baby.

Not applicable — not for use in women.

Enzalutamide may impair fertility in men. Discuss sperm banking before starting if this matters to you.

For full prescribing information see: FDA prescribing information: Xtandi (enzalutamide) — DailyMed

Storage

How to store Enzamide 40 mg Capsules

Temperature

Store below 30°C (86°F). Oral solution: check the specific product label; do not freeze.

Light & moisture

Keep in the original packaging.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Hormonal anticancer medicine: swallow whole, do not open; wash hands after handling. Women who are or could be pregnant should not handle opened capsules or the solution. Return unused medicine to a pharmacy.

Travelling

Carry in original packaging with your prescription and a specialist's letter; take the dosing syringe if you use the solution.

Reviewed for accuracy

Medically reviewed content

G. Selvaraman

G. Selvaraman

B.Pharm, M.Pharm

G. Selvaraman is a licensed clinical pharmacist with 13 years of experience. He holds a B.Pharm and M.Pharm from K.A.P. Viswanatham Government Medical College. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

Is Enzalutamide the same as Xtandi?

Enzalutamide is the active ingredient in Xtandi. A generic Enzalutamide medicine contains the same active ingredient at the same strength and is taken the same way — the main difference is cost. Always use it as prescribed by a licensed medical professional.

How is Enzamide 40 mg Capsules different from bicalutamide?

Both block the androgen receptor, but enzalutamide binds it several times more strongly and also stops it entering the nucleus and attaching to DNA. That is why it works in cancers that have stopped responding to bicalutamide. It is used at a later stage or in higher-risk disease, and it interacts with far more other medicines.

[2] NCI Drug Information: Enzalutamide

Is Enzamide 40 mg Capsules chemotherapy?

No. It is a hormone therapy that blocks testosterone's effect on the cancer. Hair loss, sickness and low blood counts are not typical; tiredness, hot flushes and raised blood pressure are the usual effects.

[2] NCI Drug Information: Enzalutamide

Why does my pharmacist want to review all my other medicines?

Enzalutamide strongly speeds up the liver enzymes that clear many common medicines — blood thinners, some heart and blood-pressure drugs, statins, antidepressants, epilepsy drugs and more — so they can stop working properly. This is one of the most interaction-prone cancer medicines; a full review before starting, and whenever a new medicine is added, is essential.

[1] FDA prescribing information: Xtandi (enzalutamide) — DailyMed

What about the seizure risk?

Seizures occurred in fewer than 1 in 100 people in the studies, but the risk is higher with a previous seizure, stroke, brain injury or medicines that lower the seizure threshold. Tell your oncologist about any of these. If you have a seizure, treatment is stopped and reviewed.

[1] FDA prescribing information: Xtandi (enzalutamide) — DailyMed

Do I still need my hormone injections?

Usually yes. Enzalutamide blocks the receptor; the injections (or surgery) stop the testicles making testosterone. Together they work better. In some early-stage settings it is used alone — follow your specialist's plan.

[3] EMA: Xtandi — European public assessment report

Is Enzamide 40 mg Capsules the same as Xtandi?

Enzamide 40 mg Capsules contains the same active ingredient, enzalutamide, as the originator brand Xtandi (which is supplied as 40 mg capsules and tablets); an oral solution delivers the same daily dose in liquid form. Generic medicines must meet the same regulatory standards for quality, safety and effectiveness. Used as prescribed by a licensed medical professional.

[3] EMA: Xtandi — European public assessment report

Why am I more likely to fall?

Tiredness, dizziness and mild memory or concentration changes are common, and long-term hormone therapy weakens bones. Take care on stairs and in the dark, ask about bone-strengthening treatment, and report any fall.

[4] Macmillan Cancer Support: Enzalutamide (Xtandi)

Do I need a prescription to order Enzamide 40 mg Capsules?

Yes. Enzalutamide is prescription-only. Upload your specialist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Xtandi (enzalutamide) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=xtandi U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Enzalutamide. https://www.cancer.gov/about-cancer/treatment/drugs/enzalutamide National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. EMA: Xtandi — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/xtandi European Medicines Agency. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Enzalutamide (Xtandi). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/enzalutamide Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #203415, NCI Drug Information, and NHS patient information.
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