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Prescription only medicine

Tafinlar 75 mg Capsules

Dabrafenib 75 mg

Tafinlar 75 mg Capsules is a trusted medication containing Dabrafenib, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Dabrafenib
Strength
75 mg
Form
Capsule
Manufacturer
Novartis
Made in
India
Prescription
Required
Commonly used forCancer
$49.00 per pack of 120 capsules

Prescription required — upload it at checkout.

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Hari Ramalingam
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Tafinlar 75 mg Capsules?

Dabrafenib is a targeted capsule for cancers that carry a particular change in the BRAF gene (a 'BRAF V600 mutation') — most often melanoma that has spread or cannot be removed by surgery, and also certain lung, thyroid and other solid tumours, including some in children. It is almost always taken together with trametinib, a MEK inhibitor: the two block consecutive steps of the same growth pathway and work better together than either alone.

Before starting, your tumour must have been tested and shown to carry the BRAF V600 mutation. Dabrafenib is not used for tumours without it, and in BRAF-normal tumours it can even stimulate growth.

Dabrafenib is taken twice a day on an empty stomach. Fever is the most common side effect of the combination and your team will give you a plan for it. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Dabrafenib work?

In BRAF-mutant cancers a faulty BRAF protein sends a permanent 'grow' signal down a chain of proteins called the MAPK pathway (RAS → RAF → MEK → ERK). Dabrafenib blocks the mutant BRAF protein itself, so the signal never starts. Trametinib blocks MEK, the next step down; using both shuts the pathway at two points, which works better and — importantly — prevents the pathway from finding a way round the block, which is what happens when a BRAF inhibitor is used alone. It also reduces the new skin growths that BRAF inhibitors alone can cause in normal skin cells.

The faulty signal

A BRAF V600E or V600K mutation keeps the BRAF kinase permanently active, driving continuous MEK/ERK signalling.

BRAF blockade

Dabrafenib binds the ATP pocket of mutant BRAF and stops it phosphorylating MEK.

Two-point shutdown

With trametinib blocking MEK below, the pathway is closed at two points, delaying resistance and limiting paradoxical activation in BRAF-normal cells.

Uses

What is Dabrafenib used for?

BRAF V600E/K-mutant melanoma (unresectable or metastatic)

With trametinib; also as adjuvant treatment for one year after complete removal of stage III melanoma.

FDA EMA CDSCO
BRAF V600E-mutant non-small cell lung cancer (metastatic)

With trametinib.

FDA EMA
BRAF V600E-mutant anaplastic thyroid cancer

With trametinib, where there is no satisfactory local treatment.

FDA
BRAF V600E-mutant solid tumours (tumour-agnostic) and paediatric low-grade glioma

With trametinib, adults and children aged one and over.

FDA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Tafinlar 75 mg Capsules

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If it is less than 6 hours until the next dose, skip the missed one. Never take two doses together.

With food? Take on an empty stomach — at least one hour before or two hours after a meal — with a full glass of water. Swallow capsules whole; do not open or chew.

Important safety information

Safety & warnings

Please read this section before taking Tafinlar 75 mg Capsules and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Fever (pyrexia), often with chills — mainly in the first months
  • Tiredness (fatigue)
  • Nausea, vomiting, diarrhoea
  • Headache, joint and muscle pain
  • Rash, dry skin, thickened skin on palms and soles
  • Raised blood sugar
  • Swelling of hands and feet
  • Raised liver enzymes
  • Hair thinning

Contact your doctor immediately if you notice:

  • Fever of 38.5°C or higher, rigors, dizziness or dehydration Contact your team the same day; both drugs are usually paused, the fever treated, and restarted once you are well — a written plan is given at the start.
  • New skin growths, warty lumps or changes to moles Report promptly — new skin cancers (cutaneous squamous cell carcinoma) can develop; skin checks are routine before, during and for six months after treatment.
  • Excessive thirst, passing lots of urine, blurred vision Contact your team — blood sugar can rise, especially in people with diabetes.
  • Blurred vision, seeing halos, eye pain Seek prompt eye assessment — uveitis or retinal problems can occur (the latter mainly from trametinib).
  • Breathlessness, swollen ankles, fast or irregular heartbeat Seek urgent review — reduced heart function or QT prolongation; heart scans and ECG are monitored.
  • Unusual bleeding: coughing or vomiting blood, black stools, severe headache Seek emergency care.
  • Severe abdominal pain, vomiting, fever Seek urgent care — pancreatitis has been reported.
  • Severe blistering rash, or rash with fever and mouth ulcers Stop and contact your team immediately.
  • Very reduced urine, dark urine, muscle pain Seek review — kidney injury and muscle breakdown have been reported, usually alongside fever.

Important: tell your doctor about these medicines

Taking Dabrafenib with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong CYP3A4 or CYP2C8 inhibitors (ketoconazole, gemfibrozil, clarithromycin, ritonavir) Major

    Increase dabrafenib levels.

  • Strong CYP3A4 or CYP2C8 inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce dabrafenib levels.

  • Hormonal contraceptives, warfarin, midazolam, dexamethasone and other CYP3A4/CYP2C9 substrates Major

    Dabrafenib is a strong inducer and can make them less effective.

Pregnancy & breastfeeding

Dabrafenib can harm an unborn baby. It should not be used in pregnancy, and women who could become pregnant should use effective contraception during treatment and for at least two weeks after the last dose (four months for the trametinib partner).

Do not breastfeed during treatment or for two weeks after the last dose.

Dabrafenib may reduce fertility, particularly sperm production in men. Discuss fertility preservation before starting if relevant.

For full prescribing information see: FDA prescribing information: Tafinlar (dabrafenib) — DailyMed

Storage

How to store Tafinlar 75 mg Capsules

Temperature

Store below 30°C (86°F).

Light & moisture

Keep in the original bottle with the desiccant, tightly closed.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Anticancer medicine: swallow capsules whole, do not open; wash hands after handling. Return unused capsules to a pharmacy.

Travelling

Carry in original packaging with your prescription and an oncologist's letter. Your trametinib needs a cool bag — plan both together.

Reviewed for accuracy

Medically reviewed content

Hari Ramalingam

Hari Ramalingam

B.Pharm

Hari Ramalingam is a licensed clinical pharmacist with 14 years of experience. He holds a B.Pharm from Dr. M.G.R. Medical University. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

FAQ

Frequently asked questions

Why is Tafinlar 75 mg Capsules given with trametinib?

Dabrafenib blocks BRAF; trametinib blocks MEK, the next step in the same pathway. Together they work better than either alone, resistance takes longer to develop, and the new skin growths seen with dabrafenib alone are much rarer. Dabrafenib on its own is now seldom used.

[4] Macmillan Cancer Support: Dabrafenib and trametinib

Do I need a BRAF test before taking Tafinlar 75 mg Capsules?

Yes. Dabrafenib only helps tumours with a BRAF V600 mutation — and in tumours without it, a BRAF inhibitor can actually speed growth. Your oncologist will have confirmed the mutation with a validated test before prescribing.

[1] FDA prescribing information: Tafinlar (dabrafenib) — DailyMed

Is fever normal on this treatment?

Fever affects most people on the dabrafenib–trametinib combination, usually in the first weeks. Your team will give you a plan — typically pausing both drugs, treating the fever, and restarting once you have been well for 24 hours. Do not manage a fever of 38.5°C or more yourself; call your team.

[4] Macmillan Cancer Support: Dabrafenib and trametinib

Why on an empty stomach?

Food — especially a high-fat meal — reduces and delays absorption. Take the capsules at least an hour before or two hours after eating, with water.

[1] FDA prescribing information: Tafinlar (dabrafenib) — DailyMed

Does Tafinlar 75 mg Capsules affect my contraceptive pill?

Yes. Dabrafenib speeds up the breakdown of hormonal contraceptives and can make them unreliable. Use a barrier method or another non-hormonal method throughout treatment and for at least four months after the last dose of trametinib.

[1] FDA prescribing information: Tafinlar (dabrafenib) — DailyMed

Why are my skin and blood sugar checked?

BRAF inhibitors can trigger new skin cancers (usually easily treated squamous cell types) in normal skin, so a dermatology check is done before starting and regularly after. Blood sugar can also rise, so it is monitored — particularly if you have diabetes.

[1] FDA prescribing information: Tafinlar (dabrafenib) — DailyMed

Do I need a prescription to order Tafinlar 75 mg Capsules?

Yes. Dabrafenib is prescription-only. Upload your oncologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Tafinlar (dabrafenib) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=tafinlar U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Dabrafenib Mesylate. https://www.cancer.gov/about-cancer/treatment/drugs/dabrafenib National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. EMA: Tafinlar — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/tafinlar European Medicines Agency. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Dabrafenib and trametinib. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/dabrafenib-and-trametinib Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #202806, NCI Drug Information, and NHS patient information.
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