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Prescription only medicine

Pelodox 20 mg Injection

Doxorubicin 20 mg · Generic equivalent of Adriamycin

Pelodox 20 mg Injection is a trusted medication containing Doxorubicin, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Doxorubicin
Strength
20 mg
Form
Injection
Manufacturer
Sun Pharmaceutical Industries Ltd.
Made in
India
Prescription
Required
Commonly used forChemotherapy Medicines
$110.00 per pack of 1 vial

Prescription required — upload it at checkout.

Generic equivalent of Adriamycin — up to 80% less than the branded price

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Reeta Malti
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Pelodox 20 mg Injection?

Doxorubicin is one of the most widely used chemotherapy medicines. It is given by drip (intravenous infusion) in a hospital or chemotherapy unit — never at home — usually every three weeks as part of a combination such as AC or FEC for breast cancer, CHOP or R-CHOP for lymphoma, or with other drugs for leukaemia, sarcomas and several other cancers.

It belongs to the anthracycline group and is recognisable by its red colour, which turns urine reddish for a day or two after each dose. Because the total amount received over a lifetime affects the heart, your team keeps a running total and checks heart function before and during treatment.

The products listed here are conventional doxorubicin vials (10, 20 and 50 mg), reconstituted and given by trained staff. Liposomal doxorubicin (Caelyx / Doxil) is a different preparation with different doses and is not interchangeable. Doxorubicin is a prescription-only medicine; a valid prescription must be provided at checkout, and it must be administered by a healthcare professional.

How it works

How does Doxorubicin work?

Doxorubicin slips between the rungs of the DNA ladder inside dividing cells and locks an enzyme (topoisomerase II) onto the DNA at the moment it is being unwound for copying. The strands break and cannot be repaired, so the cell dies. It also generates reactive oxygen molecules that damage cell membranes. Rapidly dividing cancer cells are hit hardest, but so are fast-renewing healthy cells — hair follicles, the gut lining and bone marrow — which is why hair loss, mouth soreness and low blood counts occur. Heart muscle cells are especially sensitive to the oxygen-radical damage, which is why the lifetime dose is limited.

Intercalation

Doxorubicin inserts between DNA base pairs and stabilises the topoisomerase II–DNA complex.

Strand breaks

Double-strand breaks accumulate during replication and transcription; the cell cannot repair them and undergoes apoptosis.

Oxidative damage

Redox cycling of the quinone ring generates free radicals that damage membranes — the mechanism behind its cardiotoxicity, which is cumulative.

Uses

What is Doxorubicin used for?

Breast cancer (adjuvant and metastatic)

In combination regimens such as AC, FEC, TAC.

FDA EMA CDSCO
Non-Hodgkin and Hodgkin lymphoma

CHOP / R-CHOP; ABVD for Hodgkin lymphoma.

FDA EMA CDSCO
Acute lymphoblastic and acute myeloid leukaemia

As part of induction protocols.

FDA EMA CDSCO
Soft-tissue and bone sarcomas, Wilms tumour, neuroblastoma

Adults and children, per protocol.

FDA EMA CDSCO
Ovarian, bladder, thyroid, gastric, small-cell lung cancer and others

Within specialist protocols.

FDA EMA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Pelodox 20 mg Injection

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If you miss a scheduled infusion, contact your treatment centre to rebook. Doses are not made up.

With food? Not applicable — given by infusion. Anti-sickness medicines are given beforehand and to take home.

Important safety information

Safety & warnings

Please read this section before taking Pelodox 20 mg Injection and discuss any concerns with your oncologist.

Important: Cardiomyopathy (heart muscle damage)

Doxorubicin can cause heart failure, sometimes years after treatment. The risk rises with the total lifetime dose and with prior chest radiotherapy or other anthracyclines. Heart function (echocardiogram or MUGA) is measured before starting and monitored during and after treatment; the cumulative dose is tracked and capped. Report breathlessness, swollen ankles, palpitations or unusual tiredness at any time — including long after treatment ends.

Important: Secondary malignancies

Treatment-related acute myeloid leukaemia and myelodysplasia have occurred, typically one to three years after therapy. The risk is small and is weighed against the benefit of treatment.

Important: Extravasation and tissue necrosis

If doxorubicin leaks out of the vein it can cause severe tissue damage. It is given by trained staff into a well-secured line; tell the nurse immediately of any stinging, burning, swelling or redness at the drip site during the infusion.

Important: Severe myelosuppression

Doxorubicin can cause profound falls in white cells, platelets and red cells, with the lowest point 10–14 days after each dose. Blood counts are checked before every cycle; infection during this period is a medical emergency.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Hair loss (usually complete, temporary)
  • Nausea and vomiting
  • Low white blood cells, anaemia, low platelets
  • Mouth soreness and ulcers
  • Tiredness (fatigue)
  • Red-coloured urine for 1–2 days after each dose (harmless)
  • Diarrhoea, loss of appetite
  • Darkening of nails and skin creases
  • Missed periods; early menopause
  • Skin flare in previously irradiated areas (radiation recall)

Contact your doctor immediately if you notice:

  • Fever of 38°C or higher, chills, or signs of infection — especially days 7–14 after a dose Go to the emergency department at once — neutropenic sepsis is a medical emergency.
  • Breathlessness, swollen ankles, palpitations, unusual tiredness Seek urgent review — possible heart damage (boxed warning). This applies during treatment and for years afterwards.
  • Stinging, burning, swelling or redness at the drip site during the infusion Tell the nurse immediately — the infusion is stopped to prevent tissue damage.
  • Unusual bruising, bleeding gums, nosebleeds, blood in urine or stool Contact your team the same day — possible very low platelets.
  • Mouth ulcers or diarrhoea that stop you eating and drinking Contact your team; supportive treatment is needed.
  • Rash, wheeze, swelling of face or lips during the infusion Tell the nurse immediately — possible allergic reaction.

Important: tell your doctor about these medicines

Taking Doxorubicin with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Trastuzumab and other anti-HER2 antibodies Critical

    Markedly increased risk of heart failure when given together.

  • Other anthracyclines (epirubicin, daunorubicin) and mitoxantrone Critical

    Cumulative cardiotoxicity — they count towards the same lifetime cap.

  • Strong CYP3A4 / P-gp inhibitors (ketoconazole, ritonavir, verapamil, cyclosporine) Major

    Increase doxorubicin exposure.

  • Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce doxorubicin levels.

  • Chest radiotherapy Major

    Additive heart toxicity; radiation recall skin reactions.

  • Live vaccines Critical

    Risk of serious infection while immunosuppressed.

Pregnancy & breastfeeding

Doxorubicin can harm an unborn baby and should not be used in pregnancy. Women who could become pregnant should use effective contraception during treatment and for at least six months after the last dose.

Do not breastfeed during treatment or for at least ten days after the last dose.

Doxorubicin can cause early menopause and reduce sperm production, sometimes permanently. Discuss egg, embryo or sperm freezing before your first dose if this matters to you.

For full prescribing information see: FDA prescribing information: Doxorubicin hydrochloride injection — DailyMed

Storage

How to store Pelodox 20 mg Injection

Temperature

Unopened vials of solution: refrigerate at 2–8°C (36–46°F). Powder vials: below 25°C. Check the specific product label.

Light & moisture

Keep in the outer carton to protect from light.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Cytotoxic medicine for professional preparation and administration only, with protective equipment and cytotoxic waste disposal. Do not open vials at home.

Travelling

Vials are dispatched in temperature-controlled packaging and, wherever possible, delivered directly to the treating clinic.

Reviewed for accuracy

Medically reviewed content

Reeta Malti

Reeta Malti

B.Pharm, M.Pharm

Reeta Malti is a licensed clinical pharmacist with 8 years of experience. She holds a B.Pharm and M.Pharm from Pt. Ravishankar Shukla University. At OnlineMeds, she reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

Why is my urine red after treatment?

Doxorubicin is a red compound and some of it leaves the body in urine for a day or two after each dose. It is harmless. Blood in the urine looks different and comes with other symptoms — if you are unsure, tell your team.

[4] Macmillan Cancer Support: Doxorubicin

Why does my oncologist keep a running total of my doses?

Heart damage from doxorubicin depends on the total amount received over your lifetime, not just each dose. Most people stay well below the level where risk rises steeply, and the cap is lowered if you have had chest radiotherapy or other anthracyclines. Heart scans before and during treatment add a second safeguard.

[1] FDA prescribing information: Doxorubicin hydrochloride injection — DailyMed

Will I lose my hair?

Almost certainly, usually starting two to three weeks after the first dose, and it can include eyebrows and body hair. It is temporary — hair regrows within a few months of finishing, sometimes with a different texture or colour at first. Scalp cooling reduces loss for some people; ask your unit.

[4] Macmillan Cancer Support: Doxorubicin

Can Pelodox 20 mg Injection be given at home?

No. Doxorubicin is given by trained staff into a secure line because a leak into surrounding tissue can cause serious damage, and reactions need immediate treatment. We supply the vials to you or your treating centre; a healthcare professional must prepare and administer them.

[1] FDA prescribing information: Doxorubicin hydrochloride injection — DailyMed

Is this the same as liposomal doxorubicin (Caelyx / Doxil)?

No. Liposomal doxorubicin wraps the drug in fat bubbles, which changes how it distributes, its dosing and its side effects (less heart and hair effect, more hand-foot skin reaction). The two are not interchangeable. The products on this page are conventional doxorubicin.

[3] Electronic Medicines Compendium (UK): Doxorubicin SmPC

Is Pelodox 20 mg Injection the same as Adriamycin?

Pelodox 20 mg Injection contains the same active ingredient, doxorubicin hydrochloride, at the same vial strength as the originator product Adriamycin. Generic medicines must meet the same regulatory standards for quality, safety and effectiveness. Used as prescribed by a licensed medical professional.

[3] Electronic Medicines Compendium (UK): Doxorubicin SmPC

When am I most at risk of infection?

White cells reach their lowest point about 10–14 days after each dose and recover by day 21. During that window any fever of 38°C or more is an emergency — go straight to hospital and tell them you are on chemotherapy. Do not wait to see if it settles.

[4] Macmillan Cancer Support: Doxorubicin

Do I need a prescription to order Pelodox 20 mg Injection?

Yes. Doxorubicin is prescription-only and for professional administration. Upload your oncologist's prescription at checkout; our pharmacist team reviews it and confirms delivery arrangements with your clinic before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Doxorubicin hydrochloride injection — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=doxorubicin+hydrochloride U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Doxorubicin Hydrochloride. https://www.cancer.gov/about-cancer/treatment/drugs/doxorubicinhydrochloride National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. Electronic Medicines Compendium (UK): Doxorubicin SmPC. https://www.medicines.org.uk/emc/search?q=doxorubicin Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Doxorubicin. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/doxorubicin Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on ANDA/NDA #050467 (Adriamycin), NCI Drug Information, and NHS patient information.
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