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Prescription only medicine

Nexavar 200 mg Tablets

Sorafenib 200 mg

Nexavar 200 mg Tablets is a trusted medication containing Sorafenib, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Sorafenib
Strength
200 mg
Form
Tablet
Manufacturer
Bayer
Made in
Germany
Prescription
Required
Commonly used forLiver Cancer
$2,800.00 per pack of 10 tablets

Prescription required — upload it at checkout.

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Babu S. Shetty
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Nexavar 200 mg Tablets?

Sorafenib is a targeted cancer medicine taken as a tablet. It is used for liver cancer (hepatocellular carcinoma) that cannot be removed by surgery, for advanced kidney cancer (renal cell carcinoma), and for thyroid cancer that has stopped responding to radioactive iodine.

It blocks two things at once: signals inside the cancer cell that tell it to grow (through the RAF pathway) and signals that make new blood vessels grow towards the tumour (through VEGFR and PDGFR). It was one of the first medicines of this kind and is now available as generics from licensed manufacturers.

Sorafenib is taken twice a day, continuously, without food. Hand-foot skin reaction, diarrhoea, tiredness and raised blood pressure are the common side effects and are usually managed by adjusting the dose. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Sorafenib work?

Tumours need two things to keep growing: an internal 'go' signal and a blood supply. Sorafenib interferes with both. Inside the cancer cell it blocks RAF kinases, part of the chain that carries growth messages to the nucleus. On the surface of nearby blood vessels it blocks VEGFR and PDGFR, the receptors that tell vessels to sprout towards a tumour. With the growth signal weakened and the blood supply restricted, tumour growth slows. Because healthy blood vessels use the same receptors, blood pressure can rise and skin on the hands and feet — which has a rich small-vessel supply — can become sore.

Inside the cell

Sorafenib inhibits RAF-1 and B-RAF kinases, interrupting the RAF/MEK/ERK growth-signalling cascade.

Around the tumour

It also blocks VEGFR-2, VEGFR-3 and PDGFR-β on blood-vessel cells, so the tumour cannot recruit new vessels.

Net effect

Slower cell division and a starved blood supply; in thyroid cancer, blockade of RET adds a direct effect on the tumour.

Uses

What is Sorafenib used for?

Hepatocellular carcinoma (liver cancer), unresectable

Adults with preserved liver function (Child-Pugh A).

FDA EMA CDSCO
Advanced renal cell carcinoma (kidney cancer)

After failure of, or unsuitability for, interferon or interleukin-based therapy.

FDA EMA CDSCO
Differentiated thyroid cancer, radioactive-iodine refractory

Locally advanced or metastatic, progressive disease.

FDA EMA
FLT3-mutated acute myeloid leukaemia (off-label)

Used in some centres as maintenance after stem-cell transplant under specialist supervision. Not an approved use.

Off-label

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Nexavar 200 mg Tablets

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? Skip a missed dose and take the next one at the usual time. Do not double up.

With food? Take without food — at least one hour before or two hours after a meal. A high-fat meal reduces absorption by about a third. Swallow whole with water.

Important safety information

Safety & warnings

Please read this section before taking Nexavar 200 mg Tablets and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Diarrhoea
  • Hand-foot skin reaction
  • Tiredness (fatigue)
  • Rash, dry skin, itching
  • Hair thinning (alopecia)
  • Raised blood pressure
  • Weight loss, reduced appetite
  • Nausea, mouth soreness
  • Hoarse voice
  • Low calcium, low phosphate, raised lipase

Contact your doctor immediately if you notice:

  • Vomiting blood, black stools, coughing blood, or bleeding that will not stop Seek emergency care — sorafenib increases bleeding risk.
  • Chest pain, breathlessness, sudden weakness Call emergency services — heart attack and stroke have been reported.
  • Severe headache, confusion, seizures, vision change Seek urgent care — very high blood pressure or a rare brain condition (PRES).
  • Severe abdominal pain, fever, vomiting Go to the emergency department — possible bowel perforation.
  • Painful blistering or peeling of hands and feet that stops you walking Contact your team the same day; a dose pause or reduction usually settles it.
  • Yellow skin or eyes, dark urine Contact your doctor immediately — possible liver injury.
  • Painful blistering rash with fever or mouth ulcers Stop and seek urgent care — rare severe skin reactions have occurred.
  • A wound that will not heal, or planned surgery Tell your oncologist — sorafenib is usually paused around surgery.

Important: tell your doctor about these medicines

Taking Sorafenib with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce sorafenib levels and may make it less effective.

  • Warfarin Major

    Bleeding and raised INR reported.

  • Medicines that prolong the QT interval Major

    Additive heart-rhythm risk.

Pregnancy & breastfeeding

Sorafenib can harm an unborn baby. It should not be used in pregnancy, and women who could become pregnant should use effective contraception during treatment and for at least six months after the last dose.

Do not breastfeed during treatment or for two weeks after the last dose.

Animal studies suggest sorafenib may impair fertility. Discuss fertility preservation before starting if relevant.

For full prescribing information see: FDA prescribing information: Nexavar (sorafenib) — DailyMed

Storage

How to store Nexavar 200 mg Tablets

Temperature

Store below 25°C (77°F).

Light & moisture

Keep in the original packaging, protected from moisture.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Anticancer medicine: swallow whole, do not crush; wash hands after handling. Return unused tablets to a pharmacy.

Travelling

Carry in original packaging with your prescription and an oncologist's letter. Keep to the 12-hourly schedule across time zones by shifting doses gradually, as your team advises.

Reviewed for accuracy

Medically reviewed content

Babu S. Shetty

Babu S. Shetty

B.Pharm, M.Pharm

Babu S. Shetty is a licensed clinical pharmacist with 14 years of experience. He holds a B.Pharm and M.Pharm from Mohan Kumaramangalam Medical College. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

FAQ

Frequently asked questions

Is Nexavar 200 mg Tablets chemotherapy?

No. Sorafenib is a targeted therapy — a multi-kinase inhibitor. It blocks specific growth and blood-vessel signals rather than every dividing cell, so its side effects (skin, gut, blood pressure) differ from chemotherapy. Some hair thinning can still occur.

[2] NCI Drug Information: Sorafenib Tosylate

Why without food?

A high-fat meal cuts absorption by roughly a third, so the approved dose was studied on an empty stomach. Take it at least an hour before or two hours after eating.

[1] FDA prescribing information: Nexavar (sorafenib) — DailyMed

What is hand-foot skin reaction and how do I manage it?

Tenderness, redness, thickening or blisters on palms and soles, usually within the first six weeks. Moisturise thickly twice a day, wear soft well-fitting shoes, avoid hot water and friction, and tell your team early — a short dose pause or reduction usually settles it.

[4] Macmillan Cancer Support: Sorafenib (Nexavar)

How does sorafenib compare with newer liver-cancer treatments?

Sorafenib was the first medicine shown to help in advanced liver cancer and remains widely used; newer options such as lenvatinib and immunotherapy combinations are chosen for some patients. Which is right for you depends on your liver function, other conditions and what is available — that is your oncologist's decision, not something this page can answer.

[3] EMA: Nexavar — European public assessment report

Will I lose my hair?

Hair thinning is common but usually mild and patchy rather than complete, and it generally regrows after treatment ends.

[4] Macmillan Cancer Support: Sorafenib (Nexavar)

Can I keep taking Nexavar 200 mg Tablets if I need an operation?

Tell your surgeon and oncologist in advance. Sorafenib slows wound healing and increases bleeding, so it is usually paused before planned surgery and restarted once the wound has healed.

[1] FDA prescribing information: Nexavar (sorafenib) — DailyMed

Do I need a prescription to order Nexavar 200 mg Tablets?

Yes. Sorafenib is prescription-only. Upload your oncologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Nexavar (sorafenib) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=nexavar U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Sorafenib Tosylate. https://www.cancer.gov/about-cancer/treatment/drugs/sorafenibtosylate National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. EMA: Nexavar — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/nexavar European Medicines Agency. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Sorafenib (Nexavar). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/sorafenib Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #021923, NCI Drug Information, and NHS patient information.
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