Mofilet 500 mg Tablets
Mofilet 500 mg Tablets is a trusted medication containing Mycophenolate Mofetil, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.
- Active ingredient: Mycophenolate Mofetil
- Strength: 500 mg
- Form: Tablet
- Indication: Prevention of organ rejection after kidney, heart, or liver transplant
- Manufacturer: Emcure Pharmaceuticals Ltd.
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What is Mycophenolate Mofetil?
How Does It Work?
MMF is rapidly hydrolysed to the active mycophenolic acid (MPA) after oral administration, which carries out the drug's immunosuppressive action.
MPA selectively inhibits inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in the de novo purine synthesis pathway required for DNA replication.
T and B cells rely almost exclusively on de novo purine synthesis. IMPDH inhibition therefore selectively suppresses lymphocyte proliferation while other cells use the salvage pathway.
How to Use
- 1 g twice daily (kidney transplant, adult)
- 1.5 g twice daily (heart transplant, adult)
- Take on an empty stomach; swallow whole — do not crush or chew
Take exactly as prescribed. Your prescriber's instructions replace the general guidance above.
Side Effects & Precautions
- Diarrhoea
- Nausea
- Vomiting
- Abdominal pain
- Leukopenia
- Increased susceptibility to infection
- Severe neutropenia (high infection risk)
- Progressive multifocal leukoencephalopathy (PML — rare but fatal)
- Pure red cell aplasia
- Lymphoma with prolonged immunosuppression
- Pregnancy (teratogenic — Category D/X)
- Hypersensitivity to MMF or mycophenolic acid
Generic vs Brand
Babu S. Shetty is a licensed clinical pharmacist with 14 years of experience. He holds a B.Pharm and M.Pharm from Mohan Kumaramangalam Medical College. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.
Storage & Handling
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Frequently Asked Questions
Increased susceptibility to infection and possible development of lymphoma may result from immunosuppression. Only physicians experienced in immunosuppressive therapy should prescribe.
Use during pregnancy is associated with increased risk of pregnancy loss and congenital malformations. Females of reproductive potential must use effective contraception.
Drug Interactions
| Drug / Substance | Effect | Action |
|---|---|---|
| Tacrolimus / ciclosporin (pharmacokinetic interaction) | ||
| Antacids / cholestyramine (reduce MPA absorption — separate doses) | ||
| Live vaccines (avoid during immunosuppression) | ||
| Rifampicin (reduces MPA exposure — avoid combination) | ||