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Prescription only medicine

Letrafem 2.5 mg Tablets

Letrozole 2.5 mg · Generic equivalent of Femara

Letrafem 2.5 mg Tablets is a trusted medication containing Letrozole, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Letrozole
Strength
2.5 mg
Form
Tablet
Manufacturer
ADLEY FORMULATIONS
Made in
India
Prescription
Required
Commonly used forBreast Cancer
$30.00 per pack of 10 tablets

Prescription required — upload it at checkout.

Generic equivalent of Femara — up to 80% less than the branded price

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by A. Prem Shree Nandan
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Letrafem 2.5 mg Tablets?

Letrozole is a hormone-therapy tablet for breast cancer that is hormone-receptor-positive — meaning the cancer cells grow in response to oestrogen — in women who have been through the menopause. It is used after surgery to reduce the chance of the cancer coming back (adjuvant treatment, usually for five years, sometimes longer), for advanced or metastatic disease, often with a CDK4/6 inhibitor such as palbociclib, and sometimes before surgery to shrink a tumour.

After the menopause the ovaries stop making oestrogen, but the body still produces small amounts from other hormones using an enzyme called aromatase. Letrozole blocks that enzyme almost completely, starving the cancer of oestrogen. It is not effective on its own in women who are still having periods, because the ovaries respond by making more.

Letrozole is a small tablet taken once a day with or without food, and it is inexpensive. Hot flushes, joint aches and bone thinning are the main side effects. Outside cancer it is also used, off-label, to stimulate ovulation in fertility treatment. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Letrozole work?

Oestrogen fuels most breast cancers. Before the menopause it comes mainly from the ovaries; afterwards it is made in fat, muscle and the tumour itself by converting other hormones with an enzyme called aromatase. Letrozole binds to aromatase and blocks it, cutting oestrogen production in postmenopausal women by around 98%. Without oestrogen the hormone-receptor-positive cancer cells cannot get the signal they need to grow. Because oestrogen also protects bone and joints, bone thinning and joint stiffness are the expected trade-offs, and bone density is monitored.

Aromatase blockade

Letrozole binds the haem iron of the aromatase (CYP19A1) enzyme with high affinity, reversibly and selectively.

Oestrogen depletion

Conversion of androgens to oestrogens in peripheral tissue and tumour falls; circulating oestradiol becomes almost undetectable.

Growth signal lost

Oestrogen-receptor-positive tumour cells lose their proliferation signal and stop dividing; combining with a CDK4/6 inhibitor deepens the arrest.

Uses

What is Letrozole used for?

Early hormone-receptor-positive breast cancer — adjuvant

Postmenopausal women, typically 5 years; also extended adjuvant after 5 years of tamoxifen.

FDA EMA CDSCO
Advanced or metastatic hormone-receptor-positive breast cancer

Alone or with a CDK4/6 inhibitor (palbociclib, ribociclib, abemaciclib); first-line or after tamoxifen.

FDA EMA CDSCO
Neoadjuvant (before surgery) treatment of hormone-receptor-positive breast cancer

To shrink the tumour where immediate surgery is not suitable.

EMA
Ovulation induction (fertility)

Widely used by fertility specialists, under specialist supervision only; not a licensed indication.

Off-label

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Letrafem 2.5 mg Tablets

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? Take it as soon as you remember unless it is nearly time for the next dose; never double up.

With food? With or without food. Swallow whole with water.

Important safety information

Safety & warnings

Please read this section before taking Letrafem 2.5 mg Tablets and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Hot flushes and sweats
  • Joint pain and stiffness (arthralgia)
  • Tiredness (fatigue)
  • Raised cholesterol
  • Bone thinning (osteoporosis) and fractures with long-term use
  • Muscle aches, back pain
  • Headache, dizziness
  • Nausea, reduced appetite
  • Vaginal dryness, reduced libido
  • Hair thinning, dry skin
  • Low mood, sleep disturbance

Contact your doctor immediately if you notice:

  • Sudden severe bone pain, or a fracture after a minor fall Seek assessment — bone density is monitored and bone-strengthening treatment may be advised.
  • Chest pain, breathlessness, sudden weakness or slurred speech Call emergency services — heart attack and stroke were slightly more frequent than with tamoxifen in trials.
  • Painful swollen calf, sudden breathlessness Seek urgent care — possible blood clot (less common than with tamoxifen, but reported).
  • Numbness, tingling or weakness in the hands (carpal tunnel) Tell your team; it is usually manageable and may improve with a treatment break.
  • Yellow skin or eyes, dark urine Contact your doctor — liver inflammation is rare but reported.
  • Joint pain severe enough to stop daily activities Tell your team — switching to a different aromatase inhibitor or tamoxifen often helps; do not stop without advice.

Important: tell your doctor about these medicines

Taking Letrozole with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Oestrogen-containing medicines (HRT, some vaginal oestrogens, the combined pill) Critical

    Directly oppose the effect of letrozole.

  • Tamoxifen Major

    Lowers letrozole levels by around 40% when taken together.

Pregnancy & breastfeeding

Letrozole is for postmenopausal women and can harm an unborn baby. It should not be used in pregnancy. Women whose menopausal status is uncertain should have hormone levels checked, and should use effective non-hormonal contraception during treatment and for at least three weeks after the last dose.

Do not breastfeed during treatment or for three weeks after the last dose.

Letrozole is not for use in women trying to conceive for cancer treatment; its separate off-label use for ovulation induction is managed by fertility specialists.

For full prescribing information see: FDA prescribing information: Femara (letrozole) — DailyMed

Storage

How to store Letrafem 2.5 mg Tablets

Temperature

Store below 30°C (86°F).

Light & moisture

Keep in the original blister.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Hormonal anticancer medicine: swallow whole; wash hands after handling. Return unused tablets to a pharmacy.

Travelling

Carry in original packaging with your prescription and an oncologist's letter; take enough for the whole trip — a gap of a few days is not dangerous, but do not run out for long.

Reviewed for accuracy

Medically reviewed content

A. Prem Shree Nandan

A. Prem Shree Nandan

B.Pharm, M.Pharm

A. Prem Shree Nandan is a licensed clinical pharmacist with 10 years of experience. He holds a B.Pharm and M.Pharm from Christian Medical College. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

Is Letrozole the same as Femara?

Letrozole is the active ingredient in Femara. A generic Letrozole medicine contains the same active ingredient at the same strength and is taken the same way — the main difference is cost. Always use it as prescribed by a licensed medical professional.

Is Letrafem 2.5 mg Tablets chemotherapy?

No. Letrozole is a hormone therapy — it removes the oestrogen the cancer feeds on rather than attacking dividing cells. Hair loss, sickness and low blood counts are not typical; hot flushes and joint aches are the usual effects.

[2] NCI Drug Information: Letrozole

Why only after the menopause?

Before the menopause the ovaries make most of the body's oestrogen, and if letrozole blocks the rest, the brain responds by driving the ovaries even harder. Letrozole alone therefore does not work in premenopausal women; it is used only with an injection that switches the ovaries off, or tamoxifen is chosen instead.

[4] Macmillan Cancer Support: Letrozole (Femara)

How long will I take Letrafem 2.5 mg Tablets?

After surgery, usually five years — sometimes extended to seven to ten in higher-risk cases, or given after five years of tamoxifen. In metastatic disease it continues for as long as it is working. Your oncologist will set the plan; the benefit builds over years, so try not to stop early because of side effects without discussing alternatives.

[1] FDA prescribing information: Femara (letrozole) — DailyMed

What can I do about joint aches?

Aching, stiff joints — especially in the morning — affect about a third of women. Regular gentle exercise, weight management, simple painkillers and vitamin D often help; switching to a different aromatase inhibitor or to tamoxifen resolves it for many. Tell your team rather than stopping.

[4] Macmillan Cancer Support: Letrozole (Femara)

Why is my bone density scanned?

Oestrogen protects bone, so removing it thins bones over time and raises fracture risk. A DEXA scan before starting and every one to two years, plus calcium, vitamin D, weight-bearing exercise and — if needed — a bone-strengthening medicine, keeps that risk down.

[3] NHS: Letrozole

Is Letrafem 2.5 mg Tablets the same as Femara?

Letrafem 2.5 mg Tablets contains the same active ingredient, letrozole, at the same 2.5 mg strength as the originator brand Femara. Generic medicines must meet the same regulatory standards for quality, safety and effectiveness. Used as prescribed by a licensed medical professional.

[1] FDA prescribing information: Femara (letrozole) — DailyMed

Can I use HRT or vaginal oestrogen for menopausal symptoms?

Systemic HRT is avoided — it supplies the oestrogen letrozole is removing. Low-dose vaginal oestrogen is sometimes considered for severe dryness, but only after discussion with your oncologist; non-hormonal moisturisers and lubricants are the first choice.

[4] Macmillan Cancer Support: Letrozole (Femara)

Do I need a prescription to order Letrafem 2.5 mg Tablets?

Yes. Letrozole is prescription-only. Upload your oncologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Femara (letrozole) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=femara U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Letrozole. https://www.cancer.gov/about-cancer/treatment/drugs/letrozole National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. NHS: Letrozole. https://www.nhs.uk/medicines/letrozole/ NHS England. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Letrozole (Femara). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/letrozole Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #020726, NCI Drug Information, and NHS patient information.
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