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Prescription only medicine

Regonat 40 mg Tablet

Regorafenib 40 mg · Generic equivalent of Stivarga

Regonat 40 mg Tablet is a trusted medication containing Regorafenib, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Regorafenib
Strength
40 mg
Form
Tablet
Manufacturer
Natco Pharma Ltd.
Made in
India
Prescription
Required
Commonly used forColorectal Cancer

Generic equivalent of Stivarga — up to 80% less than the branded price

Our oncology team reviews every request personally and responds within 24 hours.
Verified pharmacy Genuine medication Tracked shipping Medically reviewed by David Kelly
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Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
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About this medicine

What is Regonat 40 mg Tablet?

Regorafenib is a targeted cancer medicine taken as a tablet. It is used for bowel (colorectal) cancer that has spread and has already been treated with standard chemotherapy, for gastrointestinal stromal tumours (GIST) that no longer respond to imatinib and sunitinib, and for liver cancer (hepatocellular carcinoma) after treatment with sorafenib.

It works by blocking several of the signals that tumours use to grow and to build the blood vessels that feed them. It is a 'kinase inhibitor', not traditional chemotherapy.

Regorafenib is normally taken once a day for the first three weeks of each four-week cycle, followed by a week off. Your oncologist sets your dose and may reduce it if side effects — most often hand-foot skin reaction, tiredness, diarrhoea or raised blood pressure — need managing. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Regorafenib work?

Tumours grow by sending signals through proteins called kinases — some tell the cancer cell to divide, others tell nearby blood vessels to grow towards the tumour and feed it. Regorafenib blocks several of these kinases at once, including VEGFR (which drives new blood-vessel growth), KIT and RET (which drive some tumour cells directly) and parts of the RAF pathway. Cutting these signals slows tumour growth and starves it of blood supply. Because blood-vessel signalling is also used by healthy tissue, side effects such as raised blood pressure and skin reactions on the hands and feet are common.

Multi-target blockade

Regorafenib binds the ATP pocket of several kinases — VEGFR1–3, TIE2, KIT, RET, PDGFR, FGFR and RAF — switching off their signalling.

Anti-angiogenesis

Blocking VEGFR and TIE2 stops the tumour recruiting new blood vessels, limiting its oxygen and nutrient supply.

Direct tumour effect

Blocking KIT, RET and RAF signalling slows the division of tumour cells that depend on those pathways, such as GIST cells with KIT mutations.

Uses

What is Regorafenib used for?

Metastatic colorectal cancer

After fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF therapy and, for RAS wild-type tumours, an anti-EGFR therapy.

FDA EMA CDSCO
Gastrointestinal stromal tumour (GIST)

Locally advanced, unresectable or metastatic GIST previously treated with imatinib and sunitinib.

FDA EMA CDSCO
Hepatocellular carcinoma (liver cancer)

For patients previously treated with sorafenib.

FDA EMA CDSCO

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Regonat 40 mg Tablet

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If you miss a dose, take it the same day as soon as you remember. Do not take two doses on one day to make up for a missed one.

With food? Take after a low-fat meal (for example toast, cereal with skimmed milk, or a small sandwich) with a glass of water. Swallow tablets whole. A high-fat meal changes absorption; a fully empty stomach reduces it.

Important safety information

Safety & warnings

Please read this section before taking Regonat 40 mg Tablet and discuss any concerns with your oncologist.

Important: Hepatotoxicity (severe liver injury)

Regorafenib can cause severe and sometimes fatal liver damage. Liver function tests are checked before starting and regularly during treatment — at least every two weeks for the first two months, then monthly. Report yellowing of the skin or eyes, dark urine, severe tiredness or pain in the upper right abdomen immediately.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Hand-foot skin reaction (redness, pain, peeling on palms and soles)
  • Tiredness (fatigue) and weakness
  • Diarrhoea
  • Raised blood pressure
  • Loss of appetite and weight loss
  • Hoarse voice
  • Mouth soreness (mucositis)
  • Rash
  • Raised liver enzymes and bilirubin

Contact your doctor immediately if you notice:

  • Yellow skin or eyes, dark urine, severe tiredness, pain under the right ribs Stop and contact your oncologist immediately — possible liver injury.
  • Vomiting blood, black or bloody stools, coughing blood, heavy nosebleeds Seek emergency care — regorafenib can cause serious bleeding.
  • Severe abdominal pain with fever or vomiting Go to the emergency department — possible bowel perforation or fistula.
  • Chest pain, breathlessness, sudden weakness or slurred speech Call emergency services — possible heart attack or stroke.
  • Very high blood pressure, severe headache, confusion or seizures Seek urgent medical attention.
  • Painful blistering or peeling of the hands and feet that stops you walking Contact your team the same day; the dose may be paused or reduced.

Important: tell your doctor about these medicines

Taking Regorafenib with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong CYP3A4 inhibitors (ketoconazole, itraconazole, clarithromycin, ritonavir) Major

    Increase regorafenib levels and lower its active metabolites, raising toxicity.

  • Strong CYP3A4 inducers (rifampicin, phenytoin, carbamazepine, St John's wort) Major

    Reduce regorafenib levels and may make it less effective.

  • Warfarin and other anticoagulants Major

    Increased bleeding risk; regorafenib can raise INR.

Pregnancy & breastfeeding

Regorafenib can harm an unborn baby. It should not be used in pregnancy, and women who could become pregnant should use effective contraception during treatment and for at least eight weeks after the last dose.

Do not breastfeed during treatment or for two weeks after the last dose.

Animal studies suggest regorafenib may impair fertility. Discuss fertility preservation with your team before starting if relevant.

For full prescribing information see: FDA prescribing information: Stivarga (regorafenib) — DailyMed

Storage

How to store Regonat 40 mg Tablet

Temperature

Store below 25°C (77°F) in the original bottle with the desiccant; discard any tablets remaining seven weeks after first opening.

Light & moisture

Keep the bottle tightly closed to protect from moisture.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Regorafenib is an anticancer medicine. Swallow tablets whole; do not crush. Wash hands after handling and return unused tablets to a pharmacy.

Travelling

Carry in the original bottle with your prescription and a letter from your oncologist. Note the seven-week limit after opening.

Reviewed for accuracy

Medically reviewed content

David Kelly

David Kelly

B.Pharm

David Kelly is a licensed clinical pharmacist with 13 years of experience. He holds a B.Pharm from Delhi University. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

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Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

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Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

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Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

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No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

Is Regorafenib the same as Stivarga?

Regorafenib is the active ingredient in Stivarga. A generic Regorafenib medicine contains the same active ingredient at the same strength and is taken the same way — the main difference is cost. Always use it as prescribed by a licensed medical professional.

Is Regonat 40 mg Tablet chemotherapy?

No. Regorafenib is a targeted therapy — a kinase inhibitor — rather than conventional chemotherapy. It blocks specific signals tumours use to grow and to build blood vessels, so its side effects are different from those of chemotherapy.

[2] NCI Drug Information: Regorafenib

Why three weeks on and one week off?

The 21-days-on, 7-days-off cycle is how regorafenib was studied and approved. The break lets skin, gut and blood-pressure side effects settle. Your oncologist may also lower your dose in 40 mg steps; a lower dose you can stay on is generally preferred to a full dose you cannot tolerate.

[1] FDA prescribing information: Stivarga (regorafenib) — DailyMed

Why does Regonat 40 mg Tablet need to be taken with a low-fat meal?

Absorption was studied after a low-fat breakfast. A high-fat meal changes how much of the drug and its active metabolites reach the blood, and an empty stomach reduces absorption. Something light — toast, cereal with skimmed milk — is the usual advice.

[1] FDA prescribing information: Stivarga (regorafenib) — DailyMed

What is hand-foot skin reaction and what can I do about it?

Redness, tenderness, thickening or blistering on the palms and soles, usually in the first cycle. Moisturise generously, avoid tight shoes and hot water, and tell your team early — a short dose pause or reduction usually settles it. Do not wait until walking is painful.

[4] Macmillan Cancer Support: Regorafenib

How often will my liver be checked?

Because regorafenib carries a boxed warning for liver injury, liver blood tests are done before you start, at least every two weeks for the first two months, then monthly or as your oncologist decides. Report jaundice or dark urine between tests.

[1] FDA prescribing information: Stivarga (regorafenib) — DailyMed

Is Regonat 40 mg Tablet the same as Stivarga?

Regonat 40 mg Tablet contains the same active ingredient, regorafenib, at the same 40 mg strength as the originator brand Stivarga. Generic medicines must meet the same regulatory standards for quality, safety and effectiveness. Used as prescribed by a licensed medical professional.

[3] EMA: Stivarga — European public assessment report

Can I take blood-pressure tablets with it?

Yes — raised blood pressure is expected and is usually managed with standard blood-pressure medicines. Your blood pressure should be checked weekly for the first six weeks. Do not stop either medicine without advice.

[1] FDA prescribing information: Stivarga (regorafenib) — DailyMed

Do I need a prescription to order Regonat 40 mg Tablet?

Yes. Regorafenib is prescription-only. Upload your oncologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Stivarga (regorafenib) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=stivarga U.S. National Library of Medicine. Accessed 12 Sep 2026.
  2. 2. NCI Drug Information: Regorafenib. https://www.cancer.gov/about-cancer/treatment/drugs/regorafenib National Cancer Institute. Accessed 12 Sep 2026.
  3. 3. EMA: Stivarga — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/stivarga European Medicines Agency. Accessed 12 Sep 2026.
  4. 4. Macmillan Cancer Support: Regorafenib. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/regorafenib Accessed 12 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #203085, NCI Drug Information, and NHS patient information.
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