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Prescription only medicine

Azarest 300 mg Tablet

Azacitidine 300 mg · Generic equivalent of Onureg

Azarest 300 mg Tablet is a trusted medication containing Azacitidine, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Azacitidine
Strength
300 mg
Form
Tablet
Manufacturer
Everest Pharmaceuticals Ltd.
Made in
Bangladesh
Prescription
Required
Commonly used forCancer

Generic equivalent of Onureg — up to 80% less than the branded price

Our oncology team reviews every request personally and responds within 24 hours.
Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Nicholas Brain
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Azarest 300 mg Tablet?

Azacitidine is a medicine for blood cancers that start in the bone marrow — myelodysplastic syndromes (MDS), acute myeloid leukaemia (AML) in people who cannot have intensive chemotherapy, and chronic myelomonocytic leukaemia. It works differently from most chemotherapy: at low doses it switches back on genes that the cancer has silenced, helping abnormal marrow cells mature normally.

It comes in two very different forms. The injection (100 mg vials) is given under the skin or into a vein by trained staff, typically for seven days of each 28-day cycle, and is used for MDS, AML and CMML — often with venetoclax in AML. The tablet (300 mg, the Onureg presentation) is taken at home for 14 days of each cycle and is used only as maintenance in AML after chemotherapy has produced a remission. The doses are not interchangeable and the tablet must not be used in place of the injection.

Low blood counts, nausea and injection-site reactions are the main side effects. Azacitidine is a prescription-only medicine; a valid prescription must be provided at checkout, and the injection must be administered by a healthcare professional.

How it works

How does Azacitidine work?

Genes can be switched off by small chemical tags (methyl groups) on the DNA. In MDS and AML the cancer cells have silenced the genes that would normally tell them to mature and stop dividing. Azacitidine is a fake building block that is taken into the DNA of dividing cells and traps the enzyme that adds those tags, so with each cell division the tags are lost and the silenced genes switch back on — the cells can differentiate and die on schedule. At higher concentrations it also damages RNA and DNA directly. It does not cure the underlying condition, but it can control it for a long time and reduce the need for transfusions.

Incorporation

Azacitidine is phosphorylated and incorporated into RNA and, after conversion to decitabine triphosphate, into DNA of dividing cells.

DNMT trapping

DNA methyltransferase binds the azacytosine base irreversibly and is degraded, so daughter DNA is progressively demethylated.

Re-expression

Silenced tumour-suppressor and differentiation genes are re-expressed; at higher doses direct cytotoxicity adds to the effect.

Uses

What is Azacitidine used for?

Myelodysplastic syndromes (higher-risk)

Injection.

FDA EMA CDSCO
Acute myeloid leukaemia, not eligible for intensive chemotherapy

Injection, alone or with venetoclax.

FDA EMA CDSCO
Chronic myelomonocytic leukaemia

Injection.

FDA EMA
Acute myeloid leukaemia — maintenance after first remission

Oral tablets (Onureg presentation) only, in adults who achieved remission with chemotherapy and cannot complete intensive consolidation.

FDA EMA
Juvenile myelomonocytic leukaemia (children)

Injection, before stem-cell transplant.

EMA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Azarest 300 mg Tablet

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? Injection: contact the clinic to reschedule; the cycle is not restarted. Tablets: take the missed dose as soon as possible on the same day, then resume the usual schedule the next day; never take two doses in one day; tell your team if you vomit.

With food? Injection: not applicable; anti-sickness medicine is given beforehand. Tablets: with or without food; swallow whole — do not crush, split or chew. Anti-sickness medicine is usually taken 30 minutes before for the first two cycles.

Important safety information

Safety & warnings

Please read this section before taking Azarest 300 mg Tablet and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Low blood counts (neutrophils, platelets, red cells)
  • Nausea, vomiting, diarrhoea, constipation
  • Injection-site redness, pain, bruising (injection)
  • Tiredness (fatigue), weakness
  • Fever, chest and urinary infections
  • Reduced appetite, weight loss
  • Joint and muscle pain
  • Rash, itching
  • Dizziness, headache, sleep disturbance
  • Low potassium

Contact your doctor immediately if you notice:

  • Fever of 38°C or higher, chills, or signs of infection Go to the emergency department — neutropenic infection is a medical emergency.
  • Unusual bruising, bleeding gums, nosebleeds, blood in urine or stool Contact your team the same day — possible very low platelets.
  • Severe tiredness, breathlessness, pale skin Contact your team; transfusion may be needed.
  • Very reduced urine, muscle cramps, palpitations early in treatment Seek urgent care — tumour lysis syndrome can occur when there is a high cell count.
  • Severe abdominal pain, bloody diarrhoea Seek emergency care — necrotising bowel inflammation has been reported rarely.
  • Yellow skin or eyes, dark urine Contact your doctor immediately — liver toxicity is more likely with existing liver disease.
  • New breathlessness or dry cough Seek urgent review — lung inflammation has been reported.

Important: tell your doctor about these medicines

Taking Azacitidine with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Other bone-marrow-suppressing medicines Major

    Additive lowering of blood counts.

  • Live vaccines Critical

    Risk of serious infection while immunosuppressed.

  • Oral azacitidine substituted for the injection (or vice versa) Critical

    The doses and exposures differ several-fold; substitution has caused serious harm.

Pregnancy & breastfeeding

Azacitidine can harm an unborn baby and should not be used in pregnancy. Women who could become pregnant should use effective contraception during treatment and for at least six months after the last dose.

Do not breastfeed during treatment or for one week after the last dose.

Azacitidine may impair fertility in men and women. Discuss sperm banking or egg/embryo freezing before your first dose if relevant.

For full prescribing information see: FDA prescribing information: Vidaza (azacitidine for injection) — DailyMed

Storage

How to store Azarest 300 mg Tablet

Temperature

Injection vials (powder): store below 25°C; once reconstituted, use within the label's time limits (refrigerated suspension up to 8–22 hours depending on preparation). Tablets: store below 30°C.

Light & moisture

Keep in the original packaging.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Cytotoxic medicine. Injection: professional preparation and administration only. Tablets: swallow whole, do not crush or split; wash hands after handling; women who are or could be pregnant should not handle broken tablets. Return unused medicine to a pharmacy.

Travelling

Injection vials are dispatched to the treating clinic. Tablets: carry in original packaging with your prescription and a haematologist's letter, and a note of your dosing days.

Reviewed for accuracy

Medically reviewed content

Nicholas Brain

Nicholas Brain

B.Pharm, M.Pharm

Nicholas Brain is a licensed clinical pharmacist with 16 years of experience. He holds a B.Pharm and M.Pharm from Kannur University. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

Is Azacitidine the same as Vidaza?

Azacitidine is the active ingredient in Vidaza. A generic Azacitidine medicine contains the same active ingredient at the same strength and is taken the same way — the main difference is cost. Always use it as prescribed by a licensed medical professional.

Are the injection and the tablets interchangeable?

No — and this matters. The tablet (300 mg, Onureg-type) delivers far less drug than the injection and is approved only as maintenance after AML remission; the injection is the treatment for MDS, AML and CMML. Using one in place of the other has caused serious harm. Always check which form your haematologist prescribed.

[2] FDA prescribing information: Onureg (azacitidine tablets) — DailyMed

Is Azarest 300 mg Tablet chemotherapy?

It is classed as chemotherapy, but at the doses used it works mainly by switching silenced genes back on ("hypomethylation") rather than by killing cells outright. Hair loss is uncommon; low blood counts, nausea and tiredness are the usual effects.

[3] NCI Drug Information: Azacitidine

How long before Azarest 300 mg Tablet works?

Slowly. Blood counts often fall in the first cycles before they improve, and a response is usually judged after four to six cycles. Stopping early because counts have dropped is a common mistake — discuss any concerns with your haematologist rather than pausing yourself.

[5] Macmillan Cancer Support: Azacitidine (Vidaza)

Can I have the injection at home?

It is normally given in a day unit by trained staff, seven days in a row (or five days, a weekend break, then two). Some centres arrange home administration by a nurse. It is not self-injected.

[1] FDA prescribing information: Vidaza (azacitidine for injection) — DailyMed

Why the injection-site lumps and bruises?

Under-the-skin injections of azacitidine commonly cause redness, swelling or a bruise where they are given. Sites are rotated between the abdomen, thighs and upper arms. Tell the nurse if a site becomes very painful, hot or discharges.

[5] Macmillan Cancer Support: Azacitidine (Vidaza)

Is Azarest 300 mg Tablet the same as Vidaza / Onureg?

Azarest 300 mg Tablet contains the same active ingredient, azacitidine, at the same strength as the corresponding originator product (Vidaza injection or Onureg tablets). Generic medicines must meet the same regulatory standards for quality, safety and effectiveness. Used as prescribed by a licensed medical professional.

[4] EMA: Vidaza — European public assessment report

Will Azarest 300 mg Tablet cure my MDS?

No — only a stem-cell transplant can cure MDS or AML in suitable people. Azacitidine controls the disease, improves counts and reduces transfusions for as long as it keeps working, and is sometimes used to prepare for a transplant. Your haematologist will explain how it fits your plan.

[5] Macmillan Cancer Support: Azacitidine (Vidaza)

Do I need a prescription to order Azarest 300 mg Tablet?

Yes. Azacitidine is prescription-only, and the injection is for professional administration. Upload your haematologist's prescription at checkout; our pharmacist team reviews it and, for the injection, confirms delivery arrangements with your clinic before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Vidaza (azacitidine for injection) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=vidaza U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. FDA prescribing information: Onureg (azacitidine tablets) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=onureg U.S. National Library of Medicine. Accessed 13 Sep 2026.
  3. 3. NCI Drug Information: Azacitidine. https://www.cancer.gov/about-cancer/treatment/drugs/azacitidine National Cancer Institute. Accessed 13 Sep 2026.
  4. 4. EMA: Vidaza — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/vidaza European Medicines Agency. Accessed 13 Sep 2026.
  5. 5. Macmillan Cancer Support: Azacitidine (Vidaza). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/azacitidine Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #050794 (injection) / #214120 (tablets), NCI Drug Information, and NHS patient information.
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