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Daruvir 600 mg Tablets - Darunavir - Daruvir
by Cipla Ltd.

Daruvir 600 mg Tablets

Darunavir 600 mg

Daruvir 600 mg Tablets is a trusted medication containing Darunavir, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts
  • Active ingredient: Darunavir
  • Strength: 600 mg
  • Form: Tablet
  • Indication: HIV-1 infection
  • Manufacturer: Cipla Ltd.
Commonly used forHIV

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Overview

What is Darunavir?

Darunavir is a second-generation HIV protease inhibitor taken with ritonavir or cobicistat as a pharmacokinetic booster. It prevents HIV from maturing into infectious particles and is active against many drug-resistant HIV strains.
Mechanism

How Does It Work?

1
Binding to HIV protease

Darunavir binds tightly to the HIV-1 protease enzyme active site, preventing it from functioning.

2
Cleavage inhibition

Blocks proteolytic processing of the HIV Gag-Pol polyprotein, producing immature non-infectious virions that cannot establish new infections.

3
Resistance barrier

Unique C2-symmetric binding contacts maintain activity against most PI-resistant mutations, providing a high genetic barrier to resistance.

Dosage

How to Use

Timing
Once or twice daily depending on treatment history
How to Take
Swallow with water. Must be taken with a pharmacokinetic booster (ritonavir or cobicistat) and with food.
Frequency
Once daily (naïve) or twice daily (experienced with resistance)
With Food
Must be taken with food to maximise absorption
Alcohol
Avoid excessive alcohol
Missed Dose
Take as soon as remembered. If close to next dose, skip the missed dose. Never double dose.

Take exactly as prescribed. Your prescriber's instructions replace the general guidance above.

Safety

Side Effects & Precautions

Common Side Effects
  • Diarrhoea
  • Nausea
  • Headache
  • Rash
  • Elevated liver enzymes
  • Hyperlipidaemia
Serious Side Effects — seek help immediately
  • Severe skin reactions (Stevens-Johnson syndrome)
  • Hepatotoxicity
  • New-onset diabetes
  • Fat redistribution
Who Should Not Take This
  • Co-administration with drugs highly dependent on CYP3A (e.g. simvastatin, rifampicin, St John's Wort)
  • Sulfonamide allergy (darunavir contains a sulphonamide moiety)
Value

Generic vs Brand

Generic (OnlineMeds)
Prezista
Price
$219.00 per 60 tablets
$1200–$1800/month (US list price)
Active ingredient
Identical
Identical
Licensed manufacturers
✓
✓
Bioequivalent
✓
Reference
Sitharam Reddy
Medically reviewed by
Sitharam Reddy B.Pharm, M.Pharm

Sitharam Reddy is a licensed clinical pharmacist with 19 years of experience. He holds a B.Pharm and M.Pharm from Rajiv Gandhi University of Health Sciences. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Storage

Storage & Handling

Temperature
Room temperature 15–30°C
Light
Keep in original container
Humidity
Protect from humidity
Children
Keep out of reach of children.
Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from licensed pharmaceutical manufacturers.

Genuine Medicines

Sourced from licensed manufacturers through regulated supply channels.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

Licensed Pharmacy

Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

Does Daruvir 600 mg Tablets cure HIV?
No. Darunavir suppresses HIV replication but does not eliminate the virus from the body. It must be taken daily as part of a combination regimen to keep viral load undetectable.
Must I always take Darunavir with a booster?
Yes. Darunavir must be taken with ritonavir 100 mg or cobicistat 150 mg once daily. These boosters slow the breakdown of darunavir in the liver, keeping blood levels high enough to suppress HIV.
What foods interact with Daruvir 600 mg Tablets?
Darunavir should be taken with food to improve absorption. There are no specific food restrictions, but grapefruit juice may affect its metabolism. Avoid St John's Wort as it significantly reduces darunavir levels.
Can I switch from another protease inhibitor to Daruvir 600 mg Tablets?
Switching between HIV medications is common and should always be done under the guidance of your HIV specialist. Darunavir is often chosen for its high resistance barrier and tolerability profile.

Drug Interactions

Drug / SubstanceEffectAction
Rifampicin Dramatically reduces darunavir exposure Contraindicated
Statins (simvastatin) Darunavir increases statin exposure — risk of myopathy Avoid simvastatin; use lowest dose of other statins
Oral contraceptives Darunavir may reduce contraceptive hormone levels Use alternative or additional contraception
Warfarin Darunavir may alter warfarin levels Monitor INR closely

Approved Indications

  • HIV-1 infection in adults and children ≥ 3 years FDA / EMA

References

  1. Janssen. FDA Prescribing Information: Prezista (darunavir). ↗
  2. DHHS. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents, 2023. ↗
Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.
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