DARUVIR 300

Tablet

by DARUVIR 300

Daruvir 300 mg Tablets

Darunavir

Daruvir 300 mg Tablets is a trusted medication containing Active Pharmaceutical Ingredient, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts

Active ingredient: Darunavir
Form: Tablet
Indication: HIV-1 infection
Manufacturer: DARUVIR 300

This medicine is available to order. Contact us for current pricing and availability.

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Overview

What is Darunavir?

Darunavir is a second-generation HIV protease inhibitor taken with ritonavir or cobicistat as a pharmacokinetic booster. It prevents HIV from maturing into infectious particles and is active against many drug-resistant HIV strains.

Mechanism

How Does It Work?

Binding to HIV protease

Darunavir binds tightly to the HIV-1 protease enzyme active site, preventing it from functioning.

Cleavage inhibition

Blocks proteolytic processing of the HIV Gag-Pol polyprotein, producing immature non-infectious virions that cannot establish new infections.

Resistance barrier

Unique C2-symmetric binding contacts maintain activity against most PI-resistant mutations, providing a high genetic barrier to resistance.

Dosage

How to Use

Timing

Once or twice daily depending on treatment history

How to Take

Swallow with water. Must be taken with a pharmacokinetic booster (ritonavir or cobicistat) and with food.

Frequency

Once daily (naïve) or twice daily (experienced with resistance)

With Food

Must be taken with food to maximise absorption

Alcohol

Avoid excessive alcohol

Missed Dose

Take as soon as remembered. If close to next dose, skip the missed dose. Never double dose.

Safety

Side Effects & Precautions

Common Side Effects

Diarrhoea
Nausea
Headache
Rash
Elevated liver enzymes
Hyperlipidaemia

Serious Side Effects — seek help immediately

Severe skin reactions (Stevens-Johnson syndrome)
Hepatotoxicity
New-onset diabetes
Fat redistribution

Who Should Not Take This

Co-administration with drugs highly dependent on CYP3A (e.g. simvastatin, rifampicin, St John's Wort)
Sulfonamide allergy (darunavir contains a sulphonamide moiety)

Value

Generic vs Brand

Generic (OnlineMeds)

Prezista

Price per unit

—

$1200–$1800/month

Active ingredient

Identical

WHO-GMP certified

✓

Bioequivalent

✓

Reference

Storage

Storage & Handling

Temperature

Room temperature 15–30°C

Light

Keep in original container

Humidity

Protect from humidity

Children

Keep out of reach of children.

Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from WHO-GMP certified manufacturers.

Quality Verified

Every batch tested for purity and bioequivalence.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

Licensed Pharmacy

Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

Does Daruvir 300 mg Tablets cure HIV?

No. Darunavir suppresses HIV replication but does not eliminate the virus from the body. It must be taken daily as part of a combination regimen to keep viral load undetectable.

Must I always take Darunavir with a booster?

Yes. Darunavir must be taken with ritonavir 100 mg or cobicistat 150 mg once daily. These boosters slow the breakdown of darunavir in the liver, keeping blood levels high enough to suppress HIV.

What foods interact with Daruvir 300 mg Tablets?

Darunavir should be taken with food to improve absorption. There are no specific food restrictions, but grapefruit juice may affect its metabolism. Avoid St John's Wort as it significantly reduces darunavir levels.

Can I switch from another protease inhibitor to Daruvir 300 mg Tablets?

Switching between HIV medications is common and should always be done under the guidance of your HIV specialist. Darunavir is often chosen for its high resistance barrier and tolerability profile.

Drug Interactions

Drug / Substance	Effect	Action
Rifampicin	Dramatically reduces darunavir exposure	Contraindicated
Statins (simvastatin)	Darunavir increases statin exposure — risk of myopathy	Avoid simvastatin; use lowest dose of other statins
Oral contraceptives	Darunavir may reduce contraceptive hormone levels	Use alternative or additional contraception
Warfarin	Darunavir may alter warfarin levels	Monitor INR closely

Approved Indications

HIV-1 infection in adults and children ≥ 3 years FDA / EMA

References

Janssen. FDA Prescribing Information: Prezista (darunavir). ↗
DHHS. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents, 2023. ↗

Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.

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