by BIOCON LIMITED

Cyclophil Me 100mg Capsule

Cyclosporine 100 mg

Cyclophil Me 100mg Capsule is a trusted medication containing Cyclosporine, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Quick Facts

Active ingredient: Cyclosporine
Strength: 100 mg
Form: Capsule
Indication: Transplant rejection prophylaxis; severe rheumatoid arthritis; severe psoriasis; nephrotic syndrome
Manufacturer: BIOCON LIMITED

Commonly used forOrgan Transplant

This medicine is available to order. Contact us for current pricing and availability.

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Overview

What is Cyclosporine?

Cyclosporine is a calcineurin inhibitor and one of the foundational immunosuppressant drugs that transformed organ transplantation. It prevents rejection by blocking IL-2 production and T-cell activation. Two formulations exist — Sandimmune (conventional) and Neoral/Gengraf (microemulsion, better absorbed) — and they are NOT interchangeable without close therapeutic drug monitoring.

Mechanism

How Does It Work?

Cyclophilin binding

Cyclosporine binds the cytoplasmic protein cyclophilin A, forming a drug-protein complex inside T cells.

Calcineurin inhibition

The cyclosporine-cyclophilin complex inhibits calcineurin, a phosphatase that normally activates NFAT transcription factors in T lymphocytes.

IL-2 suppression

Without calcineurin activity, NFAT cannot enter the nucleus, so T cells fail to produce IL-2 and cannot proliferate in response to alloantigens — preventing rejection and autoimmune inflammation.

Dosage

How to Use

General guidance

Transplant: 10–15 mg/kg/day initially in 2 divided doses; tapered to lowest effective trough-guided dose
Neoral and Sandimmune are NOT bioequivalent — never switch formulations without therapeutic drug monitoring
Take consistently with respect to food and time of day for stable blood levels

Take exactly as prescribed. Your prescriber's instructions replace the general guidance above.

Safety

Side Effects & Precautions

Common Side Effects

Nephrotoxicity (dose-dependent)
Hypertension
Tremor
Hirsutism
Gingival hyperplasia
Hyperkalaemia

Serious Side Effects — seek help immediately

Chronic nephrotoxicity (cumulative kidney damage)
Hypertension requiring antihypertensive treatment
Lymphoma and skin malignancies
Neurotoxicity (encephalopathy, seizures at high levels)

Who Should Not Take This

Uncontrolled hypertension or active infections (non-transplant use)
Concurrent potassium-sparing diuretics (hyperkalaemia risk)
Concurrent nephrotoxic drugs without close monitoring

Value

Generic vs Brand

Generic (OnlineMeds)

Neoral / Sandimmune

Price

—

$300–800/month (US list price)

Active ingredient

Identical

Licensed manufacturers

✓

Bioequivalent

✓

Reference

Medically reviewed by

Chitra Shetty B.Pharm, M.Pharm

Chitra Shetty is a licensed clinical pharmacist with 14 years of experience. She holds a B.Pharm and M.Pharm from Sambalpur University. At OnlineMeds, she reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Storage

Storage & Handling

Storage

Capsules: store below 25°C in original blister

Storage 2

Oral solution: store below 30°C; do not refrigerate Sandimmune solution

Children

Keep out of reach of children.

Why OnlineMeds

Why Buy From Us

Manufacturer Direct

Sourced directly from licensed pharmaceutical manufacturers.

Genuine Medicines

Sourced from licensed manufacturers through regulated supply channels.

Global Delivery

Discreet shipping to UK, US, AU, EU and beyond.

Licensed Pharmacy

Regulated and compliant with international pharmacy standards.

FAQ

Frequently Asked Questions

What is the difference between Sandimmune and Neoral forms of Cyclosporine?

Neoral is a microemulsion with more predictable and consistent absorption. The two have different bioavailability profiles and must never be switched without blood level monitoring by your transplant team.

How often do I need blood tests with Cyclophil Me 100mg Capsule?

Initially weekly, then monthly once stable. Trough blood levels guide dosing to protect your transplanted organ while minimising kidney and other toxicity.

Can Cyclosporine damage my kidneys over time?

Yes — chronic cyclosporine nephrotoxicity is a recognised risk. Your doctor uses the lowest effective dose and monitors kidney function regularly to minimise this.

What foods or drinks should I avoid with Cyclophil Me 100mg Capsule?

Avoid grapefruit and grapefruit juice — they inhibit CYP3A4 and can raise Cyclosporine blood levels unpredictably, increasing toxicity risk.

⚠ BLACK BOX WARNING

Nephrotoxicity and hepatotoxicity — use only under supervision of physicians experienced in immunosuppressive therapy and organ transplant management.

Increased susceptibility to infection and lymphoma with concurrent immunosuppressants.

Drug Interactions

Drug / Substance	Effect	Action
Nephrotoxic drugs (aminoglycosides, NSAIDs — additive kidney damage)
CYP3A4 inhibitors (ketoconazole, diltiazem — increase cyclosporine levels)
CYP3A4 inducers (rifampicin, carbamazepine — reduce levels)
Statins (increased myopathy risk)
Grapefruit juice (increases cyclosporine levels)

References

Disclaimer: This content is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any medication. Used as prescribed by a licensed medical professional.

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