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Prescription only medicine

Maball 500 mg Injection

Rituximab 500 mg · Generic equivalent of Rituxan

Maball 500 mg Injection is a trusted medication containing Rituximab, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Rituximab
Strength
500 mg
Form
Injection
Manufacturer
Hetero
Made in
India
Prescription
Required
Commonly used forLeukemia
$715.00 per pack of 1 vial

Prescription required — upload it at checkout.

Generic equivalent of Rituxan — up to 80% less than the branded price

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Jacob T.
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Maball 500 mg Injection?

Rituximab is an antibody medicine given by drip (intravenous infusion) in a hospital or infusion clinic — it is not taken at home. It is used for cancers of B lymphocytes, including several types of non-Hodgkin lymphoma and chronic lymphocytic leukaemia, usually together with chemotherapy. Lower doses are also used for autoimmune conditions such as rheumatoid arthritis, vasculitis and pemphigus.

The products listed here are rituximab biosimilars: versions of the original antibody made by a different licensed manufacturer and approved after showing they match the reference product in structure, activity and clinical effect. Vials come as 100 mg (10 mL) and 500 mg (50 mL) and are prepared by the pharmacy for infusion.

Your dose is calculated from your body surface area and the number of infusions depends on the condition. The first infusion is given slowly with pre-medication because infusion reactions are common on the first dose. Rituximab is a prescription-only medicine; a valid prescription must be provided at checkout, and it must be administered by a healthcare professional.

How it works

How does Rituximab work?

B lymphocytes — healthy and cancerous alike — carry a marker on their surface called CD20. Rituximab is a laboratory-made antibody shaped to lock onto CD20. Once attached, it flags the cell for destruction: the immune system's killer cells and complement proteins attack it, and the antibody itself can trigger the cell to self-destruct. Because CD20 is not found on the stem cells that make new B cells, the body can rebuild its healthy B-cell population over the months after treatment.

Targeting

Rituximab binds specifically to the CD20 protein on the surface of B cells, including the malignant ones in lymphoma and CLL.

Immune destruction

The bound antibody recruits complement (CDC) and natural-killer cells (ADCC) that destroy the tagged cell.

Recovery

B-cell stem cells lack CD20 and are spared, so normal B cells return over roughly six to twelve months after the last dose.

Uses

What is Rituximab used for?

Non-Hodgkin lymphoma (follicular and diffuse large B-cell, among others)

With chemotherapy (for example R-CHOP), or alone as maintenance in follicular lymphoma.

FDA EMA CDSCO
Chronic lymphocytic leukaemia (CLL)

With fludarabine and cyclophosphamide, or other regimens chosen by your haematologist.

FDA EMA CDSCO
Rheumatoid arthritis, granulomatosis with polyangiitis, microscopic polyangiitis, pemphigus vulgaris

Non-cancer uses at different doses, under a rheumatologist or dermatologist.

FDA EMA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Maball 500 mg Injection

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If you miss a scheduled infusion, contact your treatment centre to rebook. Do not attempt to make up doses.

With food? Not applicable — given by infusion. You will usually receive paracetamol, an antihistamine and sometimes a steroid 30–60 minutes before each infusion.

Important safety information

Safety & warnings

Please read this section before taking Maball 500 mg Injection and discuss any concerns with your oncologist.

Important: Fatal infusion-related reactions

Severe, sometimes fatal reactions can occur, mostly during or within 24 hours of the first infusion: breathing difficulty, low blood pressure, hives, swelling of the throat, heart rhythm problems. Rituximab is given only where these can be treated immediately, with pre-medication and close monitoring. Tell staff at once about any itching, flushing, chills, chest tightness or breathlessness during the drip.

Important: Severe mucocutaneous reactions

Rare but serious blistering skin and mouth reactions (including Stevens–Johnson syndrome and toxic epidermal necrolysis) have occurred. Report any painful rash, blisters or mouth ulcers promptly; rituximab is stopped permanently if one occurs.

Important: Hepatitis B virus reactivation

Rituximab can reactivate hepatitis B in people who have had the infection, even years earlier, leading to liver failure. Everyone is tested for hepatitis B before the first dose; carriers are given antiviral treatment and monitored during and for many months after rituximab.

Important: Progressive multifocal leukoencephalopathy (PML)

A rare, usually fatal brain infection caused by the JC virus has occurred in people treated with rituximab. Report any new confusion, weakness on one side, vision or speech problems, or clumsiness immediately.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Infusion reactions (fever, chills, flushing, itching, headache) — mainly the first infusion
  • Low white blood cells
  • Infections (chest, urinary, sinus)
  • Tiredness, weakness
  • Nausea
  • Night sweats, rash, itching
  • Low antibody levels (hypogammaglobulinaemia) with repeated courses
  • Muscle and joint aches

Contact your doctor immediately if you notice:

  • During the infusion: breathlessness, chest tightness, swelling of lips or throat, feeling faint Tell the nurse immediately — the infusion will be stopped and treated.
  • Fever of 38°C or higher, chills, or signs of infection in the weeks after treatment Contact your team the same day or attend the emergency department.
  • Confusion, one-sided weakness, vision or speech change, unsteadiness Seek emergency care — possible PML (boxed warning).
  • Yellow skin or eyes, dark urine, right-sided abdominal pain Contact your doctor immediately — possible hepatitis B reactivation or liver injury.
  • Painful rash, blistering, mouth ulcers Seek urgent review — possible severe skin reaction (boxed warning).
  • Very reduced urine, muscle cramps, palpitations in the days after the first infusion Seek urgent care — tumour lysis syndrome can occur when many cancer cells die at once.
  • Severe abdominal pain, vomiting, black stools Seek emergency care — bowel perforation has been reported rarely with chemotherapy combinations.

Important: tell your doctor about these medicines

Taking Rituximab with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Live vaccines (MMR, yellow fever, varicella, BCG, oral typhoid) Critical

    Risk of serious infection; vaccine response is also poor while B cells are depleted.

  • Other immunosuppressants and biologics (methotrexate, other antibodies) Major

    Additive infection risk.

  • Cisplatin Major

    Kidney injury has been reported with the combination.

Pregnancy & breastfeeding

Rituximab crosses the placenta and can lower B-cell counts in the baby. It should be avoided in pregnancy unless the benefit outweighs the risk; women who could become pregnant should use effective contraception during treatment and for 12 months after the last dose.

Do not breastfeed during treatment or for at least six months after the last dose.

No specific effect on fertility has been shown, but combined chemotherapy regimens may affect it. Discuss fertility preservation before starting if relevant.

For full prescribing information see: FDA prescribing information: Rituxan (rituximab) — DailyMed

Storage

How to store Maball 500 mg Injection

Temperature

Store vials in a refrigerator at 2–8°C (36–46°F). Do not freeze. Do not shake.

Light & moisture

Keep vials in the outer carton to protect from light.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

A biological medicine for professional administration only. The infusion is prepared by the pharmacy in a sterile environment; do not open vials at home.

Travelling

Rituximab must remain refrigerated in an unbroken cold chain from dispatch to the infusion centre. It is shipped with cold packs and temperature monitoring and should be delivered directly to the treating clinic wherever possible.

Reviewed for accuracy

Medically reviewed content

Jacob T.

Jacob T.

B.Pharm, M.Pharm

Jacob T. is a licensed clinical pharmacist with 18 years of experience. He holds a B.Pharm and M.Pharm from Dr. M.G.R. Medical University. At OnlineMeds, he reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

Up to 80% less than branded

Generic oncology medicines contain the same active ingredient as the originator brand — at a fraction of the cost.

FAQ

Frequently asked questions

What is a biosimilar, and is Maball 500 mg Injection the same as MabThera?

A biosimilar is a version of a biological medicine made by a different licensed manufacturer and approved after showing it matches the original in structure, biological activity, safety and effectiveness. Maball 500 mg Injection is a rituximab biosimilar. Unlike a chemical generic it is not an identical copy — antibodies are made by living cells — but regulators require it to perform the same way. Used as prescribed by a licensed medical professional.

[3] EMA: MabThera — European public assessment report

Can I take Maball 500 mg Injection at home?

No. Rituximab is given by intravenous drip in a hospital or infusion clinic, with pre-medication and monitoring, because the first infusion in particular can cause reactions that need immediate treatment. We deliver the vials to you or your treating centre; a healthcare professional must administer them.

[1] FDA prescribing information: Rituxan (rituximab) — DailyMed

Why does the first infusion take so long?

It is started slowly and the rate increased in steps so that any infusion reaction — chills, flushing, itching, breathlessness — is caught early. The first infusion often takes four to six hours. Later infusions can be given faster if the first was tolerated.

[4] Macmillan Cancer Support: Rituximab

Why was I tested for hepatitis B?

Rituximab can wake up a hepatitis B infection that was inactive for years, which can cause serious liver damage. Everyone is screened before the first dose; if you carry the virus you will be given antiviral tablets and monitored during and after treatment. This is a routine safety step.

[1] FDA prescribing information: Rituxan (rituximab) — DailyMed

Will I catch infections more easily?

Yes, for a while. Rituximab removes healthy B cells as well as cancerous ones, so your ability to make new antibodies is reduced for six to twelve months after the last dose. Report fevers promptly, keep up non-live vaccines as your team advises, and avoid live vaccines.

[2] NCI Drug Information: Rituximab

How are the vials shipped?

Rituximab must stay between 2 and 8°C. Our vials are dispatched in validated cold-chain packaging with temperature monitoring and, wherever possible, delivered directly to your infusion centre. Do not accept a delivery that arrives warm — contact us.

How many infusions will I have?

It depends on the condition and regimen — commonly six to eight cycles with chemotherapy for lymphoma, sometimes followed by maintenance infusions every two to three months for two years. Your haematologist will give you the schedule.

[4] Macmillan Cancer Support: Rituximab

Do I need a prescription to order Maball 500 mg Injection?

Yes. Rituximab is prescription-only and for professional administration. Upload your specialist's prescription at checkout; our pharmacist team reviews it and confirms delivery arrangements with your clinic before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Rituxan (rituximab) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=rituxan U.S. National Library of Medicine. Accessed 12 Sep 2026.
  2. 2. NCI Drug Information: Rituximab. https://www.cancer.gov/about-cancer/treatment/drugs/rituximab National Cancer Institute. Accessed 12 Sep 2026.
  3. 3. EMA: MabThera — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/mabthera European Medicines Agency. Accessed 12 Sep 2026.
  4. 4. Macmillan Cancer Support: Rituximab. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/rituximab Accessed 12 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on BLA #103705, NCI Drug Information, and NHS patient information.
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