Cenforce Fm 100 mg Tablets
- Active ingredient: Sildenafil
- Form: Tablet
- Indication: Erectile dysfunction; pulmonary arterial hypertension (PAH)
- Manufacturer: Cenforce
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What is Sildenafil?
How Does It Work?
Sexual stimulation or pulmonary vasoconstriction triggers nitric oxide (NO) release, which activates guanylate cyclase to increase cyclic GMP (cGMP), causing smooth muscle relaxation and vasodilation.
Sildenafil blocks phosphodiesterase type 5 (PDE5), the enzyme that degrades cGMP in smooth muscle of the corpus cavernosum and pulmonary vasculature, prolonging and enhancing the vasodilatory effect.
In the penis this increased blood flow produces erection; in the pulmonary vasculature it reduces pulmonary vascular resistance, lowering right heart afterload in PAH.
How to Use
Side Effects & Precautions
- Headache
- Flushing
- Nasal congestion
- Dyspepsia
- Transient visual changes (blue tinge, blurring)
- Back pain
- Severe hypotension with nitrates (potentially fatal)
- Non-arteritic anterior ischaemic optic neuropathy — NAION (sudden vision loss, rare)
- Sudden sensorineural hearing loss
- Priapism (erection > 4 hours — medical emergency)
- Concurrent use of any nitrate in any form (GTN, isosorbide) — potentially fatal hypotension
- Concurrent riociguat or other sGC stimulators
- Severe hepatic impairment
- Prior NAION episode
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Storage & Handling
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