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Prescription only medicine

Xovoltib 30 mg Tablets

Afatinib Dimaleate 30 mg

Xovoltib 30 mg Tablets is a trusted medication containing Afatinib, designed for personal use under the guidance of a healthcare professional. Available for prescription-based international supply with discreet worldwide delivery.

Active ingredient
Afatinib Dimaleate
Strength
30 mg
Form
Tablet
Manufacturer
Boehringer Ingelheim
Made in
Germany
Prescription
Required
Commonly used forLung Cancer
$1,428.00 per pack of 7 tablets

Prescription required — upload it at checkout.

Verified pharmacy Genuine medication Tracked shipping Medically reviewed by Lipika Sachdeva
Licensed Pharmacy Trust & safety
Licensed Manufacturers Every medicine from a licensed manufacturer
Dedicated Oncology Team Doctor + pharmacist review every order before dispatch
Worldwide Delivery UK · US · AU · EU · NZ — tracked and insured
About this medicine

What is Xovoltib 30 mg Tablets?

Afatinib is a targeted tablet for non-small cell lung cancer whose cells carry a change (mutation) in the EGFR gene. It is used as a first treatment for metastatic EGFR-mutant lung cancer — including some of the less common mutations — and for squamous lung cancer that has progressed after platinum chemotherapy.

It is a second-generation EGFR inhibitor: it binds permanently to EGFR and its relatives HER2 and HER4, switching off the growth signal that the mutation has jammed on. Because EGFR is also important in skin and the gut lining, diarrhoea and an acne-like rash are very common and are managed with medicines your team will give you from the start.

Afatinib is taken once a day on an empty stomach. Your tumour must have been tested for an EGFR mutation before it is prescribed. It is a prescription-only medicine; a valid prescription must be provided at checkout.

How it works

How does Afatinib work?

EGFR is a receptor on the surface of lung cells that, when activated, tells the cell to grow. In some lung cancers a mutation leaves EGFR permanently switched on, and the tumour depends on that signal. Afatinib enters the cell and forms a permanent bond with the signalling part of EGFR — and of its relatives HER2 and HER4 — so the signal stops and the cancer cell dies. The bond is irreversible, which is why afatinib keeps working between doses. Normal skin and gut cells also use EGFR for day-to-day repair, so rash and diarrhoea are expected side effects rather than allergies.

Covalent binding

Afatinib bonds irreversibly to a cysteine in the kinase pocket of EGFR (ErbB1), HER2 (ErbB2) and HER4 (ErbB4).

Signal cut off

The mutant receptor can no longer activate the growth pathways beneath it (MAPK, PI3K/AKT).

Cell death

EGFR-dependent tumour cells stop dividing and die; the irreversible bond means the block lasts until the cell makes new receptor.

Uses

What is Afatinib used for?

Metastatic non-small cell lung cancer with EGFR exon 19 deletion or exon 21 (L858R) mutation

First-line. Also for certain uncommon EGFR mutations (S768I, L861Q, G719X).

FDA EMA CDSCO
Metastatic squamous non-small cell lung cancer

After progression on platinum-based chemotherapy.

FDA EMA

Only your oncologist can determine whether this medicine is right for your diagnosis. The above is for information only.

Dosage

How to take Xovoltib 30 mg Tablets

Your oncologist will prescribe your exact dose. The right dose for you depends on your weight, kidney and liver function, and — for some medicines — your genetic test results.

Always take exactly as prescribed. Do not change your dose or stop taking this medicine without speaking to your doctor first, even if you feel well.

Missed a dose? If it is more than 8 hours until the next dose, take the missed dose. Otherwise skip it. Never double up.

With food? Take on an empty stomach — no food for at least three hours before and one hour after. Food reduces absorption. Swallow whole with water.

Important safety information

Safety & warnings

Please read this section before taking Xovoltib 30 mg Tablets and discuss any concerns with your oncologist.

Common side effects

Side effects affect some people, not everyone. Most are manageable — let your treatment team know about anything that concerns you.

  • Diarrhoea
  • Acne-like rash, dry skin, itching
  • Mouth soreness and ulcers (stomatitis)
  • Nail-fold inflammation (paronychia)
  • Reduced appetite, nausea, weight loss
  • Nosebleeds
  • Conjunctivitis, dry eyes
  • Raised liver enzymes
  • Low potassium (with diarrhoea)

Contact your doctor immediately if you notice:

  • Diarrhoea that is severe, lasts more than two days, or comes with dizziness or reduced urine Contact your team the same day; start loperamide at the first loose stool as instructed and keep drinking fluids. Dehydration and kidney injury can follow.
  • New or worsening breathlessness, cough or fever Seek urgent review — lung inflammation (interstitial lung disease) is rare but serious; afatinib is stopped if confirmed.
  • Yellow skin or eyes, dark urine Contact your doctor immediately — possible liver injury.
  • Painful blistering rash, or rash with fever and mouth ulcers Stop and seek urgent care — severe skin reactions are rare but reported.
  • Eye pain, sudden vision change, severe redness Seek prompt eye assessment — keratitis can occur; do not wear contact lenses if eyes are sore.
  • Breathlessness, swollen ankles, palpitations Seek urgent review — reduced heart function has been reported.
  • Severe abdominal pain Seek urgent care — bowel perforation has been reported rarely.

Important: tell your doctor about these medicines

Taking Afatinib with certain other medicines can be dangerous. Always tell every doctor, dentist, and pharmacist about all medicines you are taking.

  • Strong P-glycoprotein inhibitors (ritonavir, cyclosporine, ketoconazole, itraconazole, erythromycin, verapamil, amiodarone) Major

    Increase afatinib levels.

  • Strong P-glycoprotein inducers (rifampicin, carbamazepine, phenytoin, St John's wort) Major

    Reduce afatinib levels.

  • Live vaccines Major

    Safety not established during active treatment.

Pregnancy & breastfeeding

Afatinib can harm an unborn baby. It should not be used in pregnancy, and women who could become pregnant should use effective contraception during treatment and for at least two weeks after the last dose.

Do not breastfeed during treatment or for two weeks after the last dose.

Effects on human fertility are not established; animal data suggest possible impairment. Discuss fertility preservation before starting if relevant.

For full prescribing information see: FDA prescribing information: Gilotrif (afatinib) — DailyMed

Storage

How to store Xovoltib 30 mg Tablets

Temperature

Store below 25°C (77°F).

Light & moisture

Keep in the original blister to protect from moisture and light.

Keep away from children

Keep out of the sight and reach of children.

Safe handling

Anticancer medicine: swallow whole, do not crush; wash hands after handling. Return unused tablets to a pharmacy.

Travelling

Carry in the original packaging with your prescription and an oncologist's letter, and take your loperamide with you.

Reviewed for accuracy

Medically reviewed content

Lipika Sachdeva

Lipika Sachdeva

B.Pharm, M.Pharm

Lipika Sachdeva is a licensed clinical pharmacist with 20 years of experience. She holds a B.Pharm and M.Pharm from Delhi University. At OnlineMeds, she reviews medicine and health content to help ensure it is accurate, evidence-based, and easy to understand.

Our commitment to you

How we support oncology patients

We understand that accessing the right cancer medicine can feel overwhelming. Here is what you can expect from us.

Personal oncology support

Every enquiry is reviewed by our oncology doctor and pharmacist team — not an automated system.

Genuine, verified medicine

Sourced exclusively from licensed pharmaceutical manufacturers. Every batch is traceable from origin to your door.

Prescription checked before dispatch

We verify every prescription with our internal medical team. No shortcuts, no exceptions.

Cold-chain logistics

Temperature-sensitive medicines shipped with appropriate packaging to maintain integrity.

Discreet, plain packaging

No pharmacy branding or product name on the outer packaging.

FAQ

Frequently asked questions

Do I need an EGFR test before taking Xovoltib 30 mg Tablets?

Yes. Afatinib only helps lung cancers that carry an activating EGFR mutation, and your oncologist will have confirmed this on a tumour sample or blood test before prescribing.

[1] FDA prescribing information: Gilotrif (afatinib) — DailyMed

How does Xovoltib 30 mg Tablets differ from gefitinib, erlotinib or osimertinib?

All target EGFR. Gefitinib and erlotinib bind reversibly; afatinib binds permanently and also blocks HER2 and HER4, which helps against some uncommon mutations. Osimertinib is a third-generation drug that also covers the T790M resistance mutation and reaches the brain. Which is best for you depends on your mutation, prior treatment and availability — your oncologist decides.

[2] NCI Drug Information: Afatinib Dimaleate

Why is diarrhoea so common, and what do I do?

EGFR helps the gut lining renew itself, so blocking it loosens the bowels in most people, usually in the first weeks. Start loperamide at the first loose stool exactly as your team instructs, drink plenty of fluids, and call if it is severe or lasts more than two days. A dose reduction usually settles it without losing effect.

[4] Macmillan Cancer Support: Afatinib (Giotrif)

What about the rash?

An acne-like rash on the face, chest and back is expected. Use fragrance-free moisturiser, sun protection, and the antibiotic cream or tablets your team prescribes. It is not an allergy and it usually improves after the first two months. Tell your team if it blisters or becomes painful.

[4] Macmillan Cancer Support: Afatinib (Giotrif)

Why must Xovoltib 30 mg Tablets be taken on an empty stomach?

Food lowers absorption significantly. Leave at least three hours after a meal and one hour before the next one, and take it with water.

[1] FDA prescribing information: Gilotrif (afatinib) — DailyMed

Can I wear contact lenses?

Afatinib can dry and irritate the eyes. If your eyes are red, sore or your vision blurs, stop wearing lenses and get them checked promptly — keratitis is uncommon but needs treatment.

[1] FDA prescribing information: Gilotrif (afatinib) — DailyMed

Do I need a prescription to order Xovoltib 30 mg Tablets?

Yes. Afatinib is prescription-only. Upload your oncologist's prescription at checkout; our pharmacist team reviews it before dispatch. Used as prescribed by a licensed medical professional.

Sources

References

  1. 1. FDA prescribing information: Gilotrif (afatinib) — DailyMed. https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=gilotrif U.S. National Library of Medicine. Accessed 13 Sep 2026.
  2. 2. NCI Drug Information: Afatinib Dimaleate. https://www.cancer.gov/about-cancer/treatment/drugs/afatinibdimaleate National Cancer Institute. Accessed 13 Sep 2026.
  3. 3. EMA: Giotrif — European public assessment report. https://www.ema.europa.eu/en/medicines/human/EPAR/giotrif European Medicines Agency. Accessed 13 Sep 2026.
  4. 4. Macmillan Cancer Support: Afatinib (Giotrif). https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/afatinib Accessed 13 Sep 2026.
Medical disclaimer: This content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a licensed healthcare professional — specifically your oncologist — before starting, changing, or stopping any medication. Information is based on NDA #201292, NCI Drug Information, and NHS patient information.
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